Confined nanoparticles growth within hollow mesoporous nanoreactors for highly efficient MRI-guided photodynamic therapy

doi:10.1016/j.cej.2019.122251

SIC OpenIR

	Confined nanoparticles growth within hollow mesoporous nanoreactors for highly efficient MRI-guided photodynamic therapy
	Du, WX; Liu, TZ; Xue, FF; Chen, Y; Chen, Q; Luo, Y; Cai, XJ; Ma, M; Chen, HR
	2020
Source Publication	CHEMICAL ENGINEERING JOURNAL
ISSN	1385-8947
Subtype	Article
Abstract	Mesoporous silica nanoparticles (MSNs) have been extensively applied as a promising carrier in biomedical application due to their excellent structure with tunable function. Based on the fact that the surfactant trimethoxyoctadecylsilane (C18TMS) could present different on/off states in different solvents, herein, an intelligent "on/off" switching strategy of site-specific co-loading MnOx and Ce6 into MSNs was proposed for the first time. The multifunctional theranostic nanoplatform, i.e., Ce6/MnOx@HMSNs-PEG (CMHP), shows a sensitive longitudinal relaxation signal to the over-expressed hydrogen peroxide (H2O2) and weak acidic pH in the tumor microenvironment (TME). Furthermore, MnOx component could react with H2O2 in TME to generate O-2, which enable to relieve tumorous hypoxia and afterwards accelerate the generation of singlet oxygen (O-1(2) ) upon laser irradiation when combined with Ce6. Both in vitro and in vivo results confirm that this constructed nanosystem can be applied to MRI-guided sufficient photodynamic therapy (PDT) with reduced side-effects.
DOI	10.1016/j.cej.2019.122251
WOS Keyword	SILICA NANOPARTICLES ; OXIDE NANOPARTICLES ; CARBON DOTS ; THERANOSTICS ; HYPOXIA
Language	英语
WOS Research Area	Engineering
Publisher	ELSEVIER SCIENCE SA
Citation statistics	Cited Times:5[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/28413
Collection	中国科学院上海硅酸盐研究所
Recommended Citation GB/T 7714	Du, WX,Liu, TZ,Xue, FF,et al. Confined nanoparticles growth within hollow mesoporous nanoreactors for highly efficient MRI-guided photodynamic therapy[J]. CHEMICAL ENGINEERING JOURNAL,2020.
APA	Du, WX.,Liu, TZ.,Xue, FF.,Chen, Y.,Chen, Q.,...&Chen, HR.(2020).Confined nanoparticles growth within hollow mesoporous nanoreactors for highly efficient MRI-guided photodynamic therapy.CHEMICAL ENGINEERING JOURNAL.
MLA	Du, WX,et al."Confined nanoparticles growth within hollow mesoporous nanoreactors for highly efficient MRI-guided photodynamic therapy".CHEMICAL ENGINEERING JOURNAL (2020).

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