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Combined Magnetic Hyperthermia and Immune Therapy for Primary and Metastatic Tumor Treatments
Pan, J; Hu, P; Guo, YD; Hao, JN; Ni, DL; Xu, YY; Bao, QQ; Yao, HL; Wei, CY; Wu, QS; Shi, JL
2020
Source PublicationACS NANO
ISSN1936-0851
Issue1Pages:1033
SubtypeArticle
AbstractCancer immunotherapy shows promising potential in future cancer treatment but unfortunately is clinically unsatisfactory due to the low therapeutic efficacy and the possible severe immunotoxicity. Here we show a combined magnetic hyperthermia therapy (MHT) and checkpoint blockade immunotherapy for both primary tumor ablation and mimetic metastatic tumor inhibition. Monodispersed, high-performance superparamagnetic CoFe2O4@MnFe2O4 nanoparticles were synthesized and used for effective MHT-induced thermal ablation of primary tumors. Simultaneously, numerous tumor-associated antigens were produced to promote the maturation and activation of dendritic cells (DCs) and cytotoxic T cells for effective immunotherapy of distant mimetic metastatic tumors in a tumor-bearing mice model. The combined MHT and checkpoint blockade immunotherapy demonstrate the great potentials in the fight against both primary and metastatic tumors.
DOI10.1021/acsnano.9b08550
WOS KeywordPHOTOTHERMAL THERAPY ; CHECKPOINT BLOCKADE ; ACQUIRED-RESISTANCE ; ANTITUMOR IMMUNITY ; CANCER ; IMMUNOTHERAPY ; NANOPARTICLES ; PD-L1 ; CRYOABLATION ; COMBINATION
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/28397
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Pan, J,Hu, P,Guo, YD,et al. Combined Magnetic Hyperthermia and Immune Therapy for Primary and Metastatic Tumor Treatments[J]. ACS NANO,2020(1):1033.
APA Pan, J.,Hu, P.,Guo, YD.,Hao, JN.,Ni, DL.,...&Shi, JL.(2020).Combined Magnetic Hyperthermia and Immune Therapy for Primary and Metastatic Tumor Treatments.ACS NANO(1),1033.
MLA Pan, J,et al."Combined Magnetic Hyperthermia and Immune Therapy for Primary and Metastatic Tumor Treatments".ACS NANO .1(2020):1033.
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