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Improved cellular bioactivity by heparin immobilization on polycarbonate film via an aminolysis modification for potential tendon repair
Guo, JS; Li, K; Ning, CQ; Liu, XY
2020
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
Pages835
SubtypeArticle
AbstractTendon repair was an important part during tendon to bone healing. In the present study, heparin molecules were immobilized on the aminolyzed PCL surface to improve the cellular bioactivity for potential tendon repair. The effects of heparin immobilization on protein adsorption behavior and cellular bioactivity of NIH3T3 and ATDC5 cells were investigated. The results were shown as follows: 1. Heparin molecules could be effectively immobilized on the PCL surface through an aminolysis modification. 2. PCL films exhibited a more negative surface after heparin immobilization. The existence of heparin enhanced the adsorption of proteins. 3. Heparin immobilized PCL sample improved the attachment and proliferation of NIH3T3 and ATDC5 cells, also enhanced the secretion of collagen and glycosaminoglycans. (C) 2019 Elsevier B.V. All rights reserved.
DOI10.1016/j.ijbiomac.2019.09.136
WOS KeywordMOLECULAR-WEIGHT HEPARIN ; CHONDROCYTE ADHESION ; PROTEIN ; SURFACE ; COLLAGEN ; PROLIFERATION ; INTERCALATION ; KINETICS ; SURGERY ; SULFATE
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
PublisherELSEVIER
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/28396
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Guo, JS,Li, K,Ning, CQ,et al. Improved cellular bioactivity by heparin immobilization on polycarbonate film via an aminolysis modification for potential tendon repair[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2020:835.
APA Guo, JS,Li, K,Ning, CQ,&Liu, XY.(2020).Improved cellular bioactivity by heparin immobilization on polycarbonate film via an aminolysis modification for potential tendon repair.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,835.
MLA Guo, JS,et al."Improved cellular bioactivity by heparin immobilization on polycarbonate film via an aminolysis modification for potential tendon repair".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020):835.
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