Bioinspired Biomaterials with a Brick-and-Mortar Microstructure Combining Mechanical and Biological Performance

doi:10.1002/adhm.201901211

SIC OpenIR

	Bioinspired Biomaterials with a Brick-and-Mortar Microstructure Combining Mechanical and Biological Performance
	Li, T; Ma, B; Xue, JM; Zhai, D; Zhao, PY; Chang, J; Wu, CT
	2020-02-01
Source Publication	ADVANCED HEALTHCARE MATERIALS
ISSN	2192-2640
Issue	4
Subtype	Article
Abstract	The fabrication of bone regeneration biomaterials, which simultaneously possess superior mechanical performances and excellent bioactivity, remains challenging because these properties are usually mutually exclusive. Herein, inspired by the brick-and-mortar architecture of nacre, lamellar silicate-based bioceramic composites are successfully prepared by constructing orderly layered bioceramics infiltrated with a biomedical resin interlayer via the bidirectional freezing technique. The lamellar composites possess high strength and proper Young's moduli, which match with human cortical bone. Furthermore, the lamellar composites can release bioactive ions with a controlled profile, which significantly enhance the cell proliferation of both rabbit bone mesenchymal stem cells and periodontal ligament cells in vitro. Moreover, with the degradation of silicate bioceramics in vivo, newly formed bone tissue can grow into the materials to present the bioceramic/new bone/resin sandwich-like lamellar microstructure. The silicate-based bioceramic composites with brick-and-mortar architecture represent an excellent biomaterial in combination of superior mechanical performances matching that of human cortical bone, and excellent bioactivity for potential load-bearing bone regeneration.
DOI	10.1002/adhm.201901211
WOS Keyword	HIGH-STRENGTH ; COMPOSITE ; HYDROXYAPATITE ; BIOCERAMICS ; SCAFFOLDS ; STIFFNESS ; NACRE ; TOUGH
Language	英语
WOS Research Area	Engineering ; Science & Technology - Other Topics ; Materials Science
Publisher	WILEY
Citation statistics	Cited Times:2[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/28374
Collection	中国科学院上海硅酸盐研究所
Recommended Citation GB/T 7714	Li, T,Ma, B,Xue, JM,et al. Bioinspired Biomaterials with a Brick-and-Mortar Microstructure Combining Mechanical and Biological Performance[J]. ADVANCED HEALTHCARE MATERIALS,2020(4).
APA	Li, T.,Ma, B.,Xue, JM.,Zhai, D.,Zhao, PY.,...&Wu, CT.(2020).Bioinspired Biomaterials with a Brick-and-Mortar Microstructure Combining Mechanical and Biological Performance.ADVANCED HEALTHCARE MATERIALS(4).
MLA	Li, T,et al."Bioinspired Biomaterials with a Brick-and-Mortar Microstructure Combining Mechanical and Biological Performance".ADVANCED HEALTHCARE MATERIALS .4(2020).

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