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Bioinspired Biomaterials with a Brick-and-Mortar Microstructure Combining Mechanical and Biological Performance
Li, T; Ma, B; Xue, JM; Zhai, D; Zhao, PY; Chang, J; Wu, CT
2020-02-01
Source PublicationADVANCED HEALTHCARE MATERIALS
ISSN2192-2640
Issue4
SubtypeArticle
AbstractThe fabrication of bone regeneration biomaterials, which simultaneously possess superior mechanical performances and excellent bioactivity, remains challenging because these properties are usually mutually exclusive. Herein, inspired by the brick-and-mortar architecture of nacre, lamellar silicate-based bioceramic composites are successfully prepared by constructing orderly layered bioceramics infiltrated with a biomedical resin interlayer via the bidirectional freezing technique. The lamellar composites possess high strength and proper Young's moduli, which match with human cortical bone. Furthermore, the lamellar composites can release bioactive ions with a controlled profile, which significantly enhance the cell proliferation of both rabbit bone mesenchymal stem cells and periodontal ligament cells in vitro. Moreover, with the degradation of silicate bioceramics in vivo, newly formed bone tissue can grow into the materials to present the bioceramic/new bone/resin sandwich-like lamellar microstructure. The silicate-based bioceramic composites with brick-and-mortar architecture represent an excellent biomaterial in combination of superior mechanical performances matching that of human cortical bone, and excellent bioactivity for potential load-bearing bone regeneration.
DOI10.1002/adhm.201901211
WOS KeywordHIGH-STRENGTH ; COMPOSITE ; HYDROXYAPATITE ; BIOCERAMICS ; SCAFFOLDS ; STIFFNESS ; NACRE ; TOUGH
Language英语
WOS Research AreaEngineering ; Science & Technology - Other Topics ; Materials Science
PublisherWILEY
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/28374
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Li, T,Ma, B,Xue, JM,et al. Bioinspired Biomaterials with a Brick-and-Mortar Microstructure Combining Mechanical and Biological Performance[J]. ADVANCED HEALTHCARE MATERIALS,2020(4).
APA Li, T.,Ma, B.,Xue, JM.,Zhai, D.,Zhao, PY.,...&Wu, CT.(2020).Bioinspired Biomaterials with a Brick-and-Mortar Microstructure Combining Mechanical and Biological Performance.ADVANCED HEALTHCARE MATERIALS(4).
MLA Li, T,et al."Bioinspired Biomaterials with a Brick-and-Mortar Microstructure Combining Mechanical and Biological Performance".ADVANCED HEALTHCARE MATERIALS .4(2020).
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