KMS Shanghai Institute of Ceramics，Chinese Academy of Sciences
| Augmenting Tumor-Starvation Therapy by Cancer Cell Autophagy Inhibition | |
| Yang, BW; Ding, L; Chen, Y; Shi, JL | |
| 2020-03-01 | |
| Source Publication | ADVANCED SCIENCE
 |
| Issue | 6 |
| Subtype | Article |
| Abstract | It was recently recognized that cancer therapeutic efficacy may be greatly compromised by an intrinsic protective mechanism called autophagy, by which cancer cells survive in harsh conditions such as starvation. Here, a synergetic strategy is described for cancer treatment by suppressing such a protective mechanism for augmenting tumor-starvation therapy. The synergetic therapy is achieved by restraining glucose metabolism using an antiglycolytic agent to predispose cancer cells to severe energy deprivation; concurrently the downstream autophagic flux and compensatory energy supplies are blocked by the autophagy inhibitor black phosphorus nanosheet. Cancer cells fail to extract their own nutrient to feed themselves, finally succumbing to therapeutic interventions and starving to death. Both in vitro and in vivo results evidence the cooperative effect between the autophagy inhibitor and antiglycolytic agent, which leads to remarkable synergetic antineoplastic outcome. It is expected that such a combinational approach by concurrently blocking exogenous and endogenous nutrition supplies will be beneficial to the design of effective tumor-specific cancer therapies in the future. |
| DOI | 10.1002/advs.201902847 |
| WOS Keyword | 2-DEOXY-D-GLUCOSE ; GLYCOLYSIS ; METABOLISM ; INDUCTION ; 2-DEOXYGLUCOSE |
| Language | 英语 |
| WOS Research Area | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| Publisher | WILEY |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sic.ac.cn/handle/331005/28361 |
| Collection | 中国科学院上海硅酸盐研究所 |
| Recommended Citation GB/T 7714 | Yang, BW,Ding, L,Chen, Y,et al. Augmenting Tumor-Starvation Therapy by Cancer Cell Autophagy Inhibition[J]. ADVANCED SCIENCE,2020(6). |
| APA | Yang, BW,Ding, L,Chen, Y,&Shi, JL.(2020).Augmenting Tumor-Starvation Therapy by Cancer Cell Autophagy Inhibition.ADVANCED SCIENCE(6). |
| MLA | Yang, BW,et al."Augmenting Tumor-Starvation Therapy by Cancer Cell Autophagy Inhibition".ADVANCED SCIENCE .6(2020). |
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