SIC OpenIR
Susceptibility-weighted imaging for metabolic pathway mapping of low-dosage nanoparticles in organisms
Song, CL; Meng, XF; Liu, YY; Shen, AJ; Shao, CL; Wang, K; Cheng, H; Fang, XM; Wang, PJ; Bu, WB
2020-02-01
Source PublicationBIOMATERIALS
ISSN0142-9612
SubtypeArticle
AbstractAccurate and noninvasive monitoring of nanoparticles' (NPs) distribution and metabolism in organism is important, especially for NPs at low-dosage, but remains challenging due to the insufficient sensitivity and resolution of the existing imaging techniques. Herein, Fe3O4 NPs with different sizes were synthesized for low-dosage NPs' metabolism study with susceptibility weighted imaging (SWI) technique. SWI, as a functional MRI technique with phase postprocessing, can sensitively detect the differences of magnetic susceptibilities between tissues, so can measure the Fe3O4 contents even at low dosage in tissues. After in vivo intravenous injection, Fe3O4 NPs could be visually distinguished in major organs (kidney, liver, spleen) by SWI, and the corresponding content changes over time were also sensitively detected, but cannot be achieved via the conventional T-2-weighted imaging (T2WI). With the SWI technique, the metabolic pathways of Fe3O4 NPs in body were mapped, revealing the critical dependence on the sizes of NPs. This is significant for the assessment of NPs' metabolic time, toxicity risk, and application potentiality. Undoubtedly, SWI is a powerful tool for real-time metabolism low-dose NPs with designed characteristics (shapes, sizes, surface properties, etc.), and noninvasive detection of targets with magnetic nano-sensors in vivo.
DOI10.1016/j.biomaterials.2019.119631
WOS KeywordIN-VIVO ; MAGNETIC-PROPERTIES ; CELL-TRACKING ; DESIGN ; NANOMATERIALS ; NANOMEDICINE
Language英语
WOS Research AreaEngineering ; Materials Science
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/28347
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Song, CL,Meng, XF,Liu, YY,et al. Susceptibility-weighted imaging for metabolic pathway mapping of low-dosage nanoparticles in organisms[J]. BIOMATERIALS,2020.
APA Song, CL.,Meng, XF.,Liu, YY.,Shen, AJ.,Shao, CL.,...&Bu, WB.(2020).Susceptibility-weighted imaging for metabolic pathway mapping of low-dosage nanoparticles in organisms.BIOMATERIALS.
MLA Song, CL,et al."Susceptibility-weighted imaging for metabolic pathway mapping of low-dosage nanoparticles in organisms".BIOMATERIALS (2020).
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