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Optimized Nanointerface Engineering of Micro/Nanostructured Titanium Implants to Enhance Cell-Nanotopography Interactions and Osseointegration
Li, K; Liu, SW; Hu, T; Razanau, I; Wu, XD; Ao, HY; Huang, LP; Xie, YT; Zheng, XB
2020-02-01
Source PublicationACS BIOMATERIALS SCIENCE & ENGINEERING
ISSN2373-9878
Issue2Pages:969
SubtypeArticle
AbstractThe success of orthopedic implants requires rapid and complete osseointegration which relies on an implant surface with optimal features. To enhance cellular function in response to the implant surface, micro- and nanoscale topography have been suggested as essential. The aim of this study was to identify an optimized Ti nanostructure and to introduce it onto a titanium plasma-sprayed titanium implant (denoted NTPS-Ti) to confer enhanced immuno-modulatory properties for optimal osseointegration. To this end, three types of titania nanostructures, namely, nanowires, nanonests, and nanoflakes, were achieved on hydrothermally prepared Ti substrates. The nanowire surface modulated protein conformation and directed integrin binding and specificity in such a way as to augment the osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) and induce a desirable osteoimmune response of RAW264.7 macrophages. In a coculture system, BMSCs on the optimized micro/nanosurface exerted enhanced effects on nonactivated or lipopolysaccharide-stimulated macrophages, causing them to adopt a less inflammatory macrophage profile. The enhanced immunomodulatory properties of BMSCs grown on NTPS-Ti depended on a ROCK-medicated cyclooxygenase-2 (COX2) pathway to increase prostaglandin E2 (PGE2) production, as evidenced by decreased production of PGE2 and concurrent inhibition of immunomodulatory properties after treatment with ROCK or COX2 inhibitors. In vivo evaluation showed that the NTPS-Ti implant resulted in enhanced osseointegration compared with the TPS-Ti and Ti implants. The results obtained in our study may provide a prospective approach for enhancing osseointegration and supporting the application of micro/nanostructured Ti implants.
DOI10.1021/acsbiomaterials.9b01717
WOS KeywordINTEGRIN ALPHA(M)BETA(2) ; FIBRINOGEN ADSORPTION ; SURFACE ; FIBRONECTIN ; DIFFERENTIATION ; ACTIVATION ; COATINGS ; PROTEIN ; DOMAIN
Language英语
WOS Research AreaMaterials Science
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/28340
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Li, K,Liu, SW,Hu, T,et al. Optimized Nanointerface Engineering of Micro/Nanostructured Titanium Implants to Enhance Cell-Nanotopography Interactions and Osseointegration[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2020(2):969.
APA Li, K.,Liu, SW.,Hu, T.,Razanau, I.,Wu, XD.,...&Zheng, XB.(2020).Optimized Nanointerface Engineering of Micro/Nanostructured Titanium Implants to Enhance Cell-Nanotopography Interactions and Osseointegration.ACS BIOMATERIALS SCIENCE & ENGINEERING(2),969.
MLA Li, K,et al."Optimized Nanointerface Engineering of Micro/Nanostructured Titanium Implants to Enhance Cell-Nanotopography Interactions and Osseointegration".ACS BIOMATERIALS SCIENCE & ENGINEERING .2(2020):969.
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