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Self-assembly hollow manganese Prussian white nanocapsules attenuate Tau-related neuropathology and cognitive decline
Cai, XJ; Zhang, K; Xie, X; Zhu, XD; Feng, J; Jin, ZM; Zhang, H; Tian, M; Chen, HR
2020-02-01
Source PublicationBIOMATERIALS
ISSN0142-9612
SubtypeArticle
AbstractAlzheimer's disease (AD) is a prevalent chronic neurodegenerative disease. However, to date, none of the developed drug candidates targeting at a single therapeutic target of AD have achieved success in clinical trials. Herein, we proposed a hypothesis of hollow manganese Prussian white nanocapsules (HMPWCs)-mediated attenuation of Tau-related pathology and alleviation of cognitive decline via simultaneously alleviating neuroinflammation, scavenging reactive oxygen species, and reducing hyperphosphorylated Tau proteins. The HMPWCs self-assemblied with manganese Prussian white analogue and bovine serum albumin via a novel biomimetic mineralization present good biocompatibility, variable valence states, and low oxidation-reduction potential. They own the outstanding capabilities of relieving oxidative stress, inhibiting Tau neuropathology, and counteracting neuroinflammation, which could be used to treat Tau-related AD-like neurodegeneration. Importantly, they can also attenuate the cognitive impairments of Tau-related AD-like rats without significant side effects. This research takes the advantages of catalytic chemistry, nanomedicine and specific neurodegenerative microenvironment together, providing an alternative efficient treatment strategy for Tau-related neurodegeneration diseases, such as AD, Pick's disease, frontotemporal dementia, Creutzfeldt-Jakob Disease and progressive supranuclear palsy.
DOI10.1016/j.biomaterials.2019.119678
WOS KeywordAGGREGATION INHIBITOR THERAPY ; ALZHEIMERS-DISEASE ; OXIDATIVE STRESS ; AMYLOID-BETA ; BLUE ANALOGS ; NEUROINFLAMMATION ; MILD ; NANOPARTICLES ; PROTEIN ; TRIALS
Language英语
WOS Research AreaEngineering ; Materials Science
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/28332
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Cai, XJ,Zhang, K,Xie, X,et al. Self-assembly hollow manganese Prussian white nanocapsules attenuate Tau-related neuropathology and cognitive decline[J]. BIOMATERIALS,2020.
APA Cai, XJ.,Zhang, K.,Xie, X.,Zhu, XD.,Feng, J.,...&Chen, HR.(2020).Self-assembly hollow manganese Prussian white nanocapsules attenuate Tau-related neuropathology and cognitive decline.BIOMATERIALS.
MLA Cai, XJ,et al."Self-assembly hollow manganese Prussian white nanocapsules attenuate Tau-related neuropathology and cognitive decline".BIOMATERIALS (2020).
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