KMS Shanghai Institute of Ceramics，Chinese Academy of Sciences
| In Situ Catalytic Reaction for Solving the Aggregation of Hydrophobic Photosensitizers in Tumor | |
| Wang, CC; Zhao, PR; Jiang, DW; Yang, GL; Xue, YD; Tang, ZM; Zhang, M; Wang, H; Jiang, XW; Wu, YL; Liu, YY; Zhang, WA; Bu, WB | |
| 2020-02-05 | |
| Source Publication | ACS APPLIED MATERIALS & INTERFACES
 |
| ISSN | 1944-8244 |
| Issue | 5Pages:5624 |
| Subtype | Article |
| Abstract | The aggregation of hydrophobic photosensitizers limits the therapeutic effect of photodynamic therapy (PDT). Improving the hydrophilicity of photosensitizers can reduce their aggregation for enhancing PDT. Herein, a nanosystem (TPFcNP) is developed by a hydrophobic photosensitizer 5,10,15,20-tetralds(4-methacryloyloxyphenyl)-porphyrin (TMPP) containing multiple carbon-carbon double bonds and a ferrocene-containing amphiphilic block copolymer (PEG-b-PMAEFc), which catalyzes hydrogen peroxide (H2O2) to produce hydroxyl radicals ((OH)-O-center dot) in a tumor microenvironment by the Fenton reaction. The (OH)-O-center dot could catalyze the addition reaction between the carbon-carbon double bonds of TMPP and overexpressed water-soluble glutathione (GSH) in tumor cells, which greatly improves the hydrophilicity of photosensitizers and reduces their aggregation. Experiments in vitro and in vivo have proved that this strategy significantly enhances the therapeutic efficacy of PDT. Catalyzing intracellular reactions in situ by making use of the tumor microenvironment will open up a new opportunity to solve the aggregation of materials in the tumor for cancer treatment. |
| DOI | 10.1021/acsami.9b21589 |
| WOS Keyword | SUPEROXIDE RADICAL-ANION ; HYDROGEN-PEROXIDE ; PHOTODYNAMIC THERAPY ; GLUTATHIONE LEVELS ; NANOPARTICLES ; EFFICIENT ; CARBON ; NANOSYSTEM ; OXYGEN |
| Language | 英语 |
| WOS Research Area | Science & Technology - Other Topics ; Materials Science |
| Publisher | AMER CHEMICAL SOC |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sic.ac.cn/handle/331005/28316 |
| Collection | 中国科学院上海硅酸盐研究所 |
| Recommended Citation GB/T 7714 | Wang, CC,Zhao, PR,Jiang, DW,et al. In Situ Catalytic Reaction for Solving the Aggregation of Hydrophobic Photosensitizers in Tumor[J]. ACS APPLIED MATERIALS & INTERFACES,2020(5):5624. |
| APA | Wang, CC.,Zhao, PR.,Jiang, DW.,Yang, GL.,Xue, YD.,...&Bu, WB.(2020).In Situ Catalytic Reaction for Solving the Aggregation of Hydrophobic Photosensitizers in Tumor.ACS APPLIED MATERIALS & INTERFACES(5),5624. |
| MLA | Wang, CC,et al."In Situ Catalytic Reaction for Solving the Aggregation of Hydrophobic Photosensitizers in Tumor".ACS APPLIED MATERIALS & INTERFACES .5(2020):5624. |
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