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In Situ Catalytic Reaction for Solving the Aggregation of Hydrophobic Photosensitizers in Tumor
Wang, CC; Zhao, PR; Jiang, DW; Yang, GL; Xue, YD; Tang, ZM; Zhang, M; Wang, H; Jiang, XW; Wu, YL; Liu, YY; Zhang, WA; Bu, WB
2020-02-05
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Issue5Pages:5624
SubtypeArticle
AbstractThe aggregation of hydrophobic photosensitizers limits the therapeutic effect of photodynamic therapy (PDT). Improving the hydrophilicity of photosensitizers can reduce their aggregation for enhancing PDT. Herein, a nanosystem (TPFcNP) is developed by a hydrophobic photosensitizer 5,10,15,20-tetralds(4-methacryloyloxyphenyl)-porphyrin (TMPP) containing multiple carbon-carbon double bonds and a ferrocene-containing amphiphilic block copolymer (PEG-b-PMAEFc), which catalyzes hydrogen peroxide (H2O2) to produce hydroxyl radicals ((OH)-O-center dot) in a tumor microenvironment by the Fenton reaction. The (OH)-O-center dot could catalyze the addition reaction between the carbon-carbon double bonds of TMPP and overexpressed water-soluble glutathione (GSH) in tumor cells, which greatly improves the hydrophilicity of photosensitizers and reduces their aggregation. Experiments in vitro and in vivo have proved that this strategy significantly enhances the therapeutic efficacy of PDT. Catalyzing intracellular reactions in situ by making use of the tumor microenvironment will open up a new opportunity to solve the aggregation of materials in the tumor for cancer treatment.
DOI10.1021/acsami.9b21589
WOS KeywordSUPEROXIDE RADICAL-ANION ; HYDROGEN-PEROXIDE ; PHOTODYNAMIC THERAPY ; GLUTATHIONE LEVELS ; NANOPARTICLES ; EFFICIENT ; CARBON ; NANOSYSTEM ; OXYGEN
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science
PublisherAMER CHEMICAL SOC
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Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/28316
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Wang, CC,Zhao, PR,Jiang, DW,et al. In Situ Catalytic Reaction for Solving the Aggregation of Hydrophobic Photosensitizers in Tumor[J]. ACS APPLIED MATERIALS & INTERFACES,2020(5):5624.
APA Wang, CC.,Zhao, PR.,Jiang, DW.,Yang, GL.,Xue, YD.,...&Bu, WB.(2020).In Situ Catalytic Reaction for Solving the Aggregation of Hydrophobic Photosensitizers in Tumor.ACS APPLIED MATERIALS & INTERFACES(5),5624.
MLA Wang, CC,et al."In Situ Catalytic Reaction for Solving the Aggregation of Hydrophobic Photosensitizers in Tumor".ACS APPLIED MATERIALS & INTERFACES .5(2020):5624.
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