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A Metal-Organic Framework (MOF) Fenton Nanoagent-Enabled Nanocatalytic Cancer Therapy in Synergy with Autophagy Inhibition
Yang, BW; Ding, L; Yao, HL; Chen, Y; Shi, JL
2020-03-01
Source PublicationADVANCED MATERIALS
ISSN0935-9648
Issue12
SubtypeArticle
AbstractNanocatalytic medicine has been developed recently to trigger intratumoral generation of highly toxic reactive oxygen species (ROS) for cancer therapy, which, unfortunately, suffers from compromised therapeutic efficacy due to a self-protective mechanism, autophagy, of cancer cells to mitigate oxidative damage. In this work, during the efforts of ROS generation by nanocatalytic medicine, a pharmacological autophagy inhibition strategy is implemented for augmenting ROS-induced oxidative damage for synergetic cancer therapy. An iron-containing metal-organic framework [MOF(Fe)] nanocatalyst as a peroxidase mimic is used to catalyze the generation of highly oxidizing center dot OH radicals specifically within cancer cells, while chloroquine is applied to deacidify lysosomes and inhibit autophagy, cutting off the self-protection pathway under severe oxidative stress. Cancer cells fail to extract their components to detoxicate and strengthen themselves, finally succumbing to the ROS-induced oxidative damage during nanocatalytic therapy. Both in vitro and in vivo results demonstrate the synergy between nanocatalytic therapy and autophagy inhibition, suggesting that such a combined strategy is applicable to amplify tumor-specific oxidative damage and may be informative to future design of therapeutic regimen.
DOI10.1002/adma.201907152
WOS KeywordHYDROGEN-PEROXIDE ; MODULATION ; BIOLOGY ; CELLS ; ROS ; POLY(ADP-RIBOSE) ; CHLOROQUINE ; MECHANISMS ; INDUCTION ; CHEMISTRY
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/28309
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Yang, BW,Ding, L,Yao, HL,et al. A Metal-Organic Framework (MOF) Fenton Nanoagent-Enabled Nanocatalytic Cancer Therapy in Synergy with Autophagy Inhibition[J]. ADVANCED MATERIALS,2020(12).
APA Yang, BW,Ding, L,Yao, HL,Chen, Y,&Shi, JL.(2020).A Metal-Organic Framework (MOF) Fenton Nanoagent-Enabled Nanocatalytic Cancer Therapy in Synergy with Autophagy Inhibition.ADVANCED MATERIALS(12).
MLA Yang, BW,et al."A Metal-Organic Framework (MOF) Fenton Nanoagent-Enabled Nanocatalytic Cancer Therapy in Synergy with Autophagy Inhibition".ADVANCED MATERIALS .12(2020).
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