A Metal-Organic Framework (MOF) Fenton Nanoagent-Enabled Nanocatalytic Cancer Therapy in Synergy with Autophagy Inhibition

doi:10.1002/adma.201907152

SIC OpenIR

	A Metal-Organic Framework (MOF) Fenton Nanoagent-Enabled Nanocatalytic Cancer Therapy in Synergy with Autophagy Inhibition
	Yang, BW; Ding, L; Yao, HL; Chen, Y; Shi, JL
	2020-03-01
Source Publication	ADVANCED MATERIALS
ISSN	0935-9648
Issue	12
Subtype	Article
Abstract	Nanocatalytic medicine has been developed recently to trigger intratumoral generation of highly toxic reactive oxygen species (ROS) for cancer therapy, which, unfortunately, suffers from compromised therapeutic efficacy due to a self-protective mechanism, autophagy, of cancer cells to mitigate oxidative damage. In this work, during the efforts of ROS generation by nanocatalytic medicine, a pharmacological autophagy inhibition strategy is implemented for augmenting ROS-induced oxidative damage for synergetic cancer therapy. An iron-containing metal-organic framework [MOF(Fe)] nanocatalyst as a peroxidase mimic is used to catalyze the generation of highly oxidizing center dot OH radicals specifically within cancer cells, while chloroquine is applied to deacidify lysosomes and inhibit autophagy, cutting off the self-protection pathway under severe oxidative stress. Cancer cells fail to extract their components to detoxicate and strengthen themselves, finally succumbing to the ROS-induced oxidative damage during nanocatalytic therapy. Both in vitro and in vivo results demonstrate the synergy between nanocatalytic therapy and autophagy inhibition, suggesting that such a combined strategy is applicable to amplify tumor-specific oxidative damage and may be informative to future design of therapeutic regimen.
DOI	10.1002/adma.201907152
WOS Keyword	HYDROGEN-PEROXIDE ; MODULATION ; BIOLOGY ; CELLS ; ROS ; POLY(ADP-RIBOSE) ; CHLOROQUINE ; MECHANISMS ; INDUCTION ; CHEMISTRY
Language	英语
WOS Research Area	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
Publisher	WILEY-V C H VERLAG GMBH
Citation statistics	Cited Times:14[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/28309
Collection	中国科学院上海硅酸盐研究所
Recommended Citation GB/T 7714	Yang, BW,Ding, L,Yao, HL,et al. A Metal-Organic Framework (MOF) Fenton Nanoagent-Enabled Nanocatalytic Cancer Therapy in Synergy with Autophagy Inhibition[J]. ADVANCED MATERIALS,2020(12).
APA	Yang, BW,Ding, L,Yao, HL,Chen, Y,&Shi, JL.(2020).A Metal-Organic Framework (MOF) Fenton Nanoagent-Enabled Nanocatalytic Cancer Therapy in Synergy with Autophagy Inhibition.ADVANCED MATERIALS(12).
MLA	Yang, BW,et al."A Metal-Organic Framework (MOF) Fenton Nanoagent-Enabled Nanocatalytic Cancer Therapy in Synergy with Autophagy Inhibition".ADVANCED MATERIALS .12(2020).

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