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Engineering 2D Mesoporous Silica@MXene-Integrated 3D-Printing Scaffolds for Combinatory Osteosarcoma Therapy and NO-Augmented Bone Regeneration
Yang, QH; Yin, HH; Xu, TM; Zhu, DY; Yin, JH; Chen, YX; Yu, XW; Gao, JJ; Zhang, CQ; Chen, Y; Gao, YS
2020-04-09
Source PublicationSMALL
ISSN1613-6810
Issue14
SubtypeArticle
AbstractThe rising concerns of the recurrence and bone deficiency in surgical treatment of malignant bone tumors have raised an urgent need of the advance of multifunctional therapeutic platforms for efficient tumor therapy and bone regeneration. Herein, the construction of a multifunctional biomaterial system is reported by the integration of 2D Nb2C MXene wrapped with S-nitrosothiol (R-SNO)-grafted mesoporous silica with 3D-printing bioactive glass (BG) scaffolds (MBS). The near infrared (NIR)-triggered photonic hyperthermia of MXene in the NIR-II biowindow and precisely controlled nitric oxide (NO) release are coordinated for multitarget ablation of bone tumors to enhance localized osteosarcoma treatment. The in situ formed phosphorus and calcium components degraded from BG scaffold promote bone-regeneration bioactivity, augmented by sufficient blood supply triggered by on-demand NO release. The tunable NO generation plays a crucial role in sequential adjuvant tumor ablation, combinatory promotion of coupled vascularization, and bone regeneration. This study demonstrates a combinatory osteosarcoma ablation and a full osseous regeneration as enabled by the implantation of MBS. The design of multifunctional scaffolds with the specific features of controllable NO release, highly efficient photothermal conversion, and stimulatory bone regeneration provides an intriguing biomaterial platform for the diversified treatment of bone tumors.
DOI10.1002/smll.201906814
WOS KeywordNITRIC-OXIDE ; SOFT-TISSUE ; MOUSE MODEL ; RELEASE ; NANOPARTICLES ; BIOMATERIALS ; CHEMOTHERAPY ; SURVIVAL ; SARCOMA ; PATHWAY
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/28282
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Yang, QH,Yin, HH,Xu, TM,et al. Engineering 2D Mesoporous Silica@MXene-Integrated 3D-Printing Scaffolds for Combinatory Osteosarcoma Therapy and NO-Augmented Bone Regeneration[J]. SMALL,2020(14).
APA Yang, QH.,Yin, HH.,Xu, TM.,Zhu, DY.,Yin, JH.,...&Gao, YS.(2020).Engineering 2D Mesoporous Silica@MXene-Integrated 3D-Printing Scaffolds for Combinatory Osteosarcoma Therapy and NO-Augmented Bone Regeneration.SMALL(14).
MLA Yang, QH,et al."Engineering 2D Mesoporous Silica@MXene-Integrated 3D-Printing Scaffolds for Combinatory Osteosarcoma Therapy and NO-Augmented Bone Regeneration".SMALL .14(2020).
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