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Cathodic protected Mn2+ by NaxWO3 nanorods for stable magnetic resonance imaging-guided tumor photothermal therapy
Liu, Y; Wu, SM; Liu, YY; Zhang, H; Zhang, M; Tang, ZM; Wang, Y; Gong, T; Yao, ZW; Fang, XM; Bu, WB
2020-03-01
Source PublicationBIOMATERIALS
ISSN0142-9612
SubtypeArticle
AbstractThe stability and safety of magnetic resonance imaging (MRI) contrast agents (CAs) are crucial for accurate diagnosis and real-time monitor of tumor development. Paramagnetic Mn2+ as nonlanthanide metal ion has been widely studied for use in T-1-MRI CAs, but unfortunately, Mn2+ can be oxidized by H2O2 in tumor to nonparamagnetic Mn4+ via a Fenton-like reaction. The concurrent loss of paramagnetism and production of toxic hydroxyl radical (center dot OH) go against the basic requirment of CAs, thus restricting the further development of Mn2+-based CM. Based on the different standard potential of W6+/W5+ (similar to 0.26 V) and Mn4+/Mn2+ (similar to 1.2 V), a "cathodic protection" strategy was exploited in Mn2+-doped NaxWO3 nanorods (NaxMnWO3), with W5+ as the sacrificial anode and Mn2+ as the protected cathode, to protect Mn2+ from oxidation in tumor for stable MR contrast performance, as well as repress its Fenton-like reaction activity for good biosafety. Moreover, the tungsten bronze crystal structure endows NaxMnWO3 with excellent near-infrared (NIR)-photothennal properties for effective tumor hyperthermia, without effect from the changed oxidation state of W. This "cathodic protection" strategy offers a new method for the development of reliable and hypotoxic biomaterials for stable imaging and therapeutic applications in clinic.
DOI10.1016/j.biomaterials.2020.119762
WOS KeywordBRAIN
Language英语
WOS Research AreaEngineering ; Materials Science
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/28266
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Liu, Y,Wu, SM,Liu, YY,et al. Cathodic protected Mn2+ by NaxWO3 nanorods for stable magnetic resonance imaging-guided tumor photothermal therapy[J]. BIOMATERIALS,2020.
APA Liu, Y.,Wu, SM.,Liu, YY.,Zhang, H.,Zhang, M.,...&Bu, WB.(2020).Cathodic protected Mn2+ by NaxWO3 nanorods for stable magnetic resonance imaging-guided tumor photothermal therapy.BIOMATERIALS.
MLA Liu, Y,et al."Cathodic protected Mn2+ by NaxWO3 nanorods for stable magnetic resonance imaging-guided tumor photothermal therapy".BIOMATERIALS (2020).
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