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3D printing of Haversian bone-mimicking scaffolds for multicellular delivery in bone regeneration
Zhang, M; Lin, RC; Wang, X; Xue, JM; Deng, CJ; Feng, C; Zhuang, H; Ma, JG; Qin, C; Wan, L; Chang, J; Wu, CT
2020-03-01
Source PublicationSCIENCE ADVANCES
ISSN2375-2548
Issue12
SubtypeArticle
AbstractThe integration of structure and function for tissue engineering scaffolds is of great importance in mimicking native bone tissue. However, the complexity of hierarchical structures, the requirement for mechanical properties, and the diversity of bone resident cells are the major challenges in constructing biomimetic bone tissue engineering scaffolds. Herein, a Haversian bone- mimicking scaffold with integrated hierarchical Haversian bone structure was successfully prepared via digital laser processing (DLP)-based 3D printing. The compressive strength and porosity of scaffolds could be well controlled by altering the parameters of the Haversian bone-mimicking structure. The Haversian bone-mimicking scaffolds showed great potential for multicellular delivery by inducing osteogenic, angiogenic, and neurogenic differentiation in vitro and accelerated the ingrowth of blood vessels and new bone formation in vivo. The work offers a new strategy for designing structured and functionalized biomaterials through mimicking native complex bone tissue for tissue regeneration.
DOI10.1126/sciadv.aaz6725
WOS KeywordMESENCHYMAL STEM-CELLS ; ENDOTHELIAL-CELLS ; DIFFERENTIATION ; HYDROGEL ; GELATIN
Language英语
WOS Research AreaScience & Technology - Other Topics
PublisherAMER ASSOC ADVANCEMENT SCIENCE
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/28257
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Zhang, M,Lin, RC,Wang, X,et al. 3D printing of Haversian bone-mimicking scaffolds for multicellular delivery in bone regeneration[J]. SCIENCE ADVANCES,2020(12).
APA Zhang, M.,Lin, RC.,Wang, X.,Xue, JM.,Deng, CJ.,...&Wu, CT.(2020).3D printing of Haversian bone-mimicking scaffolds for multicellular delivery in bone regeneration.SCIENCE ADVANCES(12).
MLA Zhang, M,et al."3D printing of Haversian bone-mimicking scaffolds for multicellular delivery in bone regeneration".SCIENCE ADVANCES .12(2020).
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