3D printing of Haversian bone-mimicking scaffolds for multicellular delivery in bone regeneration

doi:10.1126/sciadv.aaz6725

SIC OpenIR

	3D printing of Haversian bone-mimicking scaffolds for multicellular delivery in bone regeneration
	Zhang, M; Lin, RC; Wang, X; Xue, JM; Deng, CJ; Feng, C; Zhuang, H; Ma, JG; Qin, C; Wan, L; Chang, J; Wu, CT
	2020-03-01
Source Publication	SCIENCE ADVANCES
ISSN	2375-2548
Issue	12
Subtype	Article
Abstract	The integration of structure and function for tissue engineering scaffolds is of great importance in mimicking native bone tissue. However, the complexity of hierarchical structures, the requirement for mechanical properties, and the diversity of bone resident cells are the major challenges in constructing biomimetic bone tissue engineering scaffolds. Herein, a Haversian bone- mimicking scaffold with integrated hierarchical Haversian bone structure was successfully prepared via digital laser processing (DLP)-based 3D printing. The compressive strength and porosity of scaffolds could be well controlled by altering the parameters of the Haversian bone-mimicking structure. The Haversian bone-mimicking scaffolds showed great potential for multicellular delivery by inducing osteogenic, angiogenic, and neurogenic differentiation in vitro and accelerated the ingrowth of blood vessels and new bone formation in vivo. The work offers a new strategy for designing structured and functionalized biomaterials through mimicking native complex bone tissue for tissue regeneration.
DOI	10.1126/sciadv.aaz6725
WOS Keyword	MESENCHYMAL STEM-CELLS ; ENDOTHELIAL-CELLS ; DIFFERENTIATION ; HYDROGEL ; GELATIN
Language	英语
WOS Research Area	Science & Technology - Other Topics
Publisher	AMER ASSOC ADVANCEMENT SCIENCE
Citation statistics	Cited Times:6[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/28257
Collection	中国科学院上海硅酸盐研究所
Recommended Citation GB/T 7714	Zhang, M,Lin, RC,Wang, X,et al. 3D printing of Haversian bone-mimicking scaffolds for multicellular delivery in bone regeneration[J]. SCIENCE ADVANCES,2020(12).
APA	Zhang, M.,Lin, RC.,Wang, X.,Xue, JM.,Deng, CJ.,...&Wu, CT.(2020).3D printing of Haversian bone-mimicking scaffolds for multicellular delivery in bone regeneration.SCIENCE ADVANCES(12).
MLA	Zhang, M,et al."3D printing of Haversian bone-mimicking scaffolds for multicellular delivery in bone regeneration".SCIENCE ADVANCES .12(2020).

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