SIC OpenIR
GSH/pH dual-responsive supramolecular hybrid vesicles for synergistic enzymatic/chemo-tumor therapy
He, JP; Chen, JZ; Niu, DC; Jia, XB; Wang, QH; Hao, JN; Gu, JL; Li, YS; Shi, JL
2020-03-01
Source PublicationAPPLIED MATERIALS TODAY
ISSN2352-9407
SubtypeArticle
AbstractSupramolecular amphiphilic vesicles are promising carriers in tumor therapy due to their excellent loading capabilities for both hydrophilic and hydrophobic cargos, especially for biomacromolecules such as proteins, enzymes and plasmids. However, the poor circulating stability and unsatisfied therapeutic efficiency greatly limit their in vivo applications. To address these issues, herein, we design and develop a new kind of GSH/pH dual-responsive supramolecular hybrid vesicles (SHVs) to encapsulate and deliver simultaneously biomacromolecule glucose oxidase (GOD) and chemotherapeutic drug docetaxel (DTX) for synergistic enzymatic/chemo-tumor therapy. The SHVs are constructed by the self-assembly of beta-CD-poly(epsilon-caprolactone), ferrocene-poly (acrylic acid) and pillar [5] arenes via the terminal beta-CD/Fc host-guest interaction, followed by cross-linking with 3-mercaptopropyltrimethoxysilane and poly (ethylene glycol) modification. As a vehicle for both hydrophilic and hydrophobic cargos, the resulting GOD/DTX co-loaded SHVs exhibit excellent synergistic enzymatic/chemo-tumor therapeutic ability with a combination index (CI = 0.285) of GOD and DTX in cellular level and high tumor inhibitory rate of 95.3% in vivo. Consequently, the resulting hybrid vesicles can be used as efficient and safe carriers for biomacromolecules in further cancer therapy. (C) 2019 Elsevier Ltd. All rights reserved.
DOI10.1016/j.apmt.2019.100458
WOS KeywordMICELLES ; PROTEINS ; POLYMERS ; DELIVERY
Language英语
WOS Research AreaMaterials Science
PublisherELSEVIER
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/28242
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
He, JP,Chen, JZ,Niu, DC,et al. GSH/pH dual-responsive supramolecular hybrid vesicles for synergistic enzymatic/chemo-tumor therapy[J]. APPLIED MATERIALS TODAY,2020.
APA He, JP.,Chen, JZ.,Niu, DC.,Jia, XB.,Wang, QH.,...&Shi, JL.(2020).GSH/pH dual-responsive supramolecular hybrid vesicles for synergistic enzymatic/chemo-tumor therapy.APPLIED MATERIALS TODAY.
MLA He, JP,et al."GSH/pH dual-responsive supramolecular hybrid vesicles for synergistic enzymatic/chemo-tumor therapy".APPLIED MATERIALS TODAY (2020).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[He, JP]'s Articles
[Chen, JZ]'s Articles
[Niu, DC]'s Articles
Baidu academic
Similar articles in Baidu academic
[He, JP]'s Articles
[Chen, JZ]'s Articles
[Niu, DC]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[He, JP]'s Articles
[Chen, JZ]'s Articles
[Niu, DC]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.