SIC OpenIR
Design strategy of optical probes for tumor hypoxia imaging
Xue, FF; Chen, JF; Chen, HR
2020-03-07
Source PublicationSCIENCE CHINA-LIFE SCIENCES
ISSN1674-7305
SubtypeReview; Early Access
AbstractClinical manifestations of tumors indicate that malignant phenotypes developing in the hypoxic microenvironment lead to resistance to cancer treatment, rendering chemotherapy, radiotherapy, and photodynamic therapy less sensitive and effective in patients with tumor. Visualizing the oxygen level in the tumor environment has garnered much attention due to its implications in precision tumor therapy. Following the rapid development of biomaterials in nanotechnology, various nanomaterials have been designed to visualize the oxygen levels in tumors. Here, we review recent research on detecting oxygen levels in solid tumors for tumor hypoxia imaging. To monitor the hypoxic level of tumors, two main strategies were investigated: directly detecting oxygen levels in tumors and monitoring the hypoxia-assisted reduced microenvironment. We believe that hypoxia as a tumor-specific microenvironment can be a breakthrough in the clinical treatment of tumors.
DOI10.1007/s11427-019-1569-4
WOS KeywordINDUCIBLE FACTOR-I ; EXTRACELLULAR-MATRIX ; NANOPARTICLE THERAPEUTICS ; FLUORESCENT-PROBES ; GENE-EXPRESSION ; DENDRITIC CELLS ; DRUG-DELIVERY ; STROMAL CELLS ; SOLID TUMORS ; CANCER
Language英语
WOS Research AreaLife Sciences & Biomedicine - Other Topics
PublisherSCIENCE PRESS
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/28237
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Xue, FF,Chen, JF,Chen, HR. Design strategy of optical probes for tumor hypoxia imaging[J]. SCIENCE CHINA-LIFE SCIENCES,2020.
APA Xue, FF,Chen, JF,&Chen, HR.(2020).Design strategy of optical probes for tumor hypoxia imaging.SCIENCE CHINA-LIFE SCIENCES.
MLA Xue, FF,et al."Design strategy of optical probes for tumor hypoxia imaging".SCIENCE CHINA-LIFE SCIENCES (2020).
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