Design strategy of optical probes for tumor hypoxia imaging

doi:10.1007/s11427-019-1569-4

SIC OpenIR

	Design strategy of optical probes for tumor hypoxia imaging
	Xue, FF; Chen, JF; Chen, HR
	2020-03-07
Source Publication	SCIENCE CHINA-LIFE SCIENCES
ISSN	1674-7305
Subtype	Review; Early Access
Abstract	Clinical manifestations of tumors indicate that malignant phenotypes developing in the hypoxic microenvironment lead to resistance to cancer treatment, rendering chemotherapy, radiotherapy, and photodynamic therapy less sensitive and effective in patients with tumor. Visualizing the oxygen level in the tumor environment has garnered much attention due to its implications in precision tumor therapy. Following the rapid development of biomaterials in nanotechnology, various nanomaterials have been designed to visualize the oxygen levels in tumors. Here, we review recent research on detecting oxygen levels in solid tumors for tumor hypoxia imaging. To monitor the hypoxic level of tumors, two main strategies were investigated: directly detecting oxygen levels in tumors and monitoring the hypoxia-assisted reduced microenvironment. We believe that hypoxia as a tumor-specific microenvironment can be a breakthrough in the clinical treatment of tumors.
DOI	10.1007/s11427-019-1569-4
WOS Keyword	INDUCIBLE FACTOR-I ; EXTRACELLULAR-MATRIX ; NANOPARTICLE THERAPEUTICS ; FLUORESCENT-PROBES ; GENE-EXPRESSION ; DENDRITIC CELLS ; DRUG-DELIVERY ; STROMAL CELLS ; SOLID TUMORS ; CANCER
Language	英语
WOS Research Area	Life Sciences & Biomedicine - Other Topics
Publisher	SCIENCE PRESS
Citation statistics	Cited Times:1[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/28237
Collection	中国科学院上海硅酸盐研究所
Recommended Citation GB/T 7714	Xue, FF,Chen, JF,Chen, HR. Design strategy of optical probes for tumor hypoxia imaging[J]. SCIENCE CHINA-LIFE SCIENCES,2020.
APA	Xue, FF,Chen, JF,&Chen, HR.(2020).Design strategy of optical probes for tumor hypoxia imaging.SCIENCE CHINA-LIFE SCIENCES.
MLA	Xue, FF,et al."Design strategy of optical probes for tumor hypoxia imaging".SCIENCE CHINA-LIFE SCIENCES (2020).

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