SIC OpenIR
A self-assembled carrier-free nanosonosensitizer for photoacoustic imaging-guided synergistic chemo-sonodynamic cancer therapy
Dong, CH; Jiang, QZ; Qian, XQ; Wu, WC; Wang, WP; Yu, LD; Chen, Y
2020-03-07
Source PublicationNANOSCALE
ISSN2040-3364
Issue9Pages:5587
SubtypeArticle
AbstractAs one of the most promising noninvasive therapeutic modalities, sonodynamic therapy (SDT) can focus the ultrasound energy on tumor sites located in deep tissue and locally activate the preloaded sonosensitizer to kill tumor cells. However, exploring sonosensitizers with high SDT efficacy and desirable biosafety is still a significant challenge. Herein, we utilized the hydrophilic-hydrophobic self-assembly technology to assemble the hydrophobic organic dye Ce6 and broad spectral anti-cancer agent Paclitaxel with hydrophilic organic dye IR783 to generate a nanoscale sonosensitizer, Ce6-PTX@IR783, without the introduction of extra nanomaterials into the fabrication to guarantee high therapeutic biosafety and further potential clinical translation. The constructed nanodrug was endowed with an external ultrasound-activatable chemo-sonodynamic effect and photoacoustic imaging performance via integrating multiple moieties into one nanosystem. Ce6 could enhance the sonodynamic effect, while PTX exerted a chemotherapeutic effect, and IR783 was applied to increase tumor-specific accumulation and assist in fulfilling photoacoustic imaging. In particular, the small particle size (70 nm) of Ce6-PTX@IR783 contributed to the increased tumor accumulation via the enhanced permeability and retention effect. The high synergistically chemo-sonodynamic therapeutic efficacy has been successfully demonstrated in vitro and in vivo, in addition to the demonstrated high biodegradability, biocompatibility and biosafety. This facile self-assembly procedure provides an intriguing strategy for highly efficient utilization of hydrophobic drugs and is liable to realize large-scale production and further clinical translation.
DOI10.1039/c9nr10735e
WOS KeywordINTENSITY FOCUSED ULTRASOUND ; DIRECT CYTOSOLIC DELIVERY ; PHOTOTHERMAL THERAPY ; NANOPARTICLES ; MECHANISM ; PROBES ; TUMORS
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/28235
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Dong, CH,Jiang, QZ,Qian, XQ,et al. A self-assembled carrier-free nanosonosensitizer for photoacoustic imaging-guided synergistic chemo-sonodynamic cancer therapy[J]. NANOSCALE,2020(9):5587.
APA Dong, CH.,Jiang, QZ.,Qian, XQ.,Wu, WC.,Wang, WP.,...&Chen, Y.(2020).A self-assembled carrier-free nanosonosensitizer for photoacoustic imaging-guided synergistic chemo-sonodynamic cancer therapy.NANOSCALE(9),5587.
MLA Dong, CH,et al."A self-assembled carrier-free nanosonosensitizer for photoacoustic imaging-guided synergistic chemo-sonodynamic cancer therapy".NANOSCALE .9(2020):5587.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Dong, CH]'s Articles
[Jiang, QZ]'s Articles
[Qian, XQ]'s Articles
Baidu academic
Similar articles in Baidu academic
[Dong, CH]'s Articles
[Jiang, QZ]'s Articles
[Qian, XQ]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Dong, CH]'s Articles
[Jiang, QZ]'s Articles
[Qian, XQ]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.