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Design of a Multifunctional Biomaterial Inspired by Ancient Chinese Medicine for Hair Regeneration in Burned Skin
Zhang, ZWB; Dai, QX; Zhang, Y; Zhuang, H; Wang, ED; Xu, Q; Ma, LL; Wu, CT; Huan, ZG; Guo, F; Chang, J
2020-03-18
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Issue11Pages:12489
SubtypeArticle
AbstractIn deep burn injuries, the dermis of the skin is often severely damaged, and hair follicles are also lost and lose the potential for regeneration. Therefore, the development of wound dressings that promote hair follicle regeneration has important clinical significance. In this study, inspired by an ancient Chinese medicine prescription, a novel fibrous membrane (P/Qu/Cup; P, PCL; Qu, quercetin; Cup, cuprorivaite, CaCuSi4O10) containing quercetin-copper (Qu-Cu) chelates was fabricated by using quercetin and a highly bioactive bioceramic (CaCuSi4O10) incorporated in PCL/gelatin electrospun fibers. The fibrous membrane can effectively release Qu and Cu ions to induce proliferation, migration, and differentiation of skin and hair follicle related cells, and the Qu, Cu ions, and Si ions released from the composite membrane revealed synergistic activity to stimulate hair follicle regeneration and wound healing. Our study demonstrated that the analysis of the common components in ancient Chinese prescription is an effective approach to design novel bioactive materials for regenerative medicine.
DOI10.1021/acsami.9b22769
WOS KeywordIN-VITRO ; QUERCETIN ; FOLLICLE ; ANTIOXIDANT ; NANOPARTICLES ; COMPLEXES ; HYDROGELS ; GROWTH ; COPPER ; CELLS
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/28221
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Zhang, ZWB,Dai, QX,Zhang, Y,et al. Design of a Multifunctional Biomaterial Inspired by Ancient Chinese Medicine for Hair Regeneration in Burned Skin[J]. ACS APPLIED MATERIALS & INTERFACES,2020(11):12489.
APA Zhang, ZWB.,Dai, QX.,Zhang, Y.,Zhuang, H.,Wang, ED.,...&Chang, J.(2020).Design of a Multifunctional Biomaterial Inspired by Ancient Chinese Medicine for Hair Regeneration in Burned Skin.ACS APPLIED MATERIALS & INTERFACES(11),12489.
MLA Zhang, ZWB,et al."Design of a Multifunctional Biomaterial Inspired by Ancient Chinese Medicine for Hair Regeneration in Burned Skin".ACS APPLIED MATERIALS & INTERFACES .11(2020):12489.
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