Design of a Multifunctional Biomaterial Inspired by Ancient Chinese Medicine for Hair Regeneration in Burned Skin

doi:10.1021/acsami.9b22769

SIC OpenIR

	Design of a Multifunctional Biomaterial Inspired by Ancient Chinese Medicine for Hair Regeneration in Burned Skin
	Zhang, ZWB; Dai, QX; Zhang, Y; Zhuang, H; Wang, ED; Xu, Q; Ma, LL; Wu, CT; Huan, ZG; Guo, F; Chang, J
	2020-03-18
Source Publication	ACS APPLIED MATERIALS & INTERFACES
ISSN	1944-8244
Issue	11 Pages:12489
Subtype	Article
Abstract	In deep burn injuries, the dermis of the skin is often severely damaged, and hair follicles are also lost and lose the potential for regeneration. Therefore, the development of wound dressings that promote hair follicle regeneration has important clinical significance. In this study, inspired by an ancient Chinese medicine prescription, a novel fibrous membrane (P/Qu/Cup; P, PCL; Qu, quercetin; Cup, cuprorivaite, CaCuSi4O10) containing quercetin-copper (Qu-Cu) chelates was fabricated by using quercetin and a highly bioactive bioceramic (CaCuSi4O10) incorporated in PCL/gelatin electrospun fibers. The fibrous membrane can effectively release Qu and Cu ions to induce proliferation, migration, and differentiation of skin and hair follicle related cells, and the Qu, Cu ions, and Si ions released from the composite membrane revealed synergistic activity to stimulate hair follicle regeneration and wound healing. Our study demonstrated that the analysis of the common components in ancient Chinese prescription is an effective approach to design novel bioactive materials for regenerative medicine.
DOI	10.1021/acsami.9b22769
WOS Keyword	IN-VITRO ; QUERCETIN ; FOLLICLE ; ANTIOXIDANT ; NANOPARTICLES ; COMPLEXES ; HYDROGELS ; GROWTH ; COPPER ; CELLS
Language	英语
WOS Research Area	Science & Technology - Other Topics ; Materials Science
Publisher	AMER CHEMICAL SOC
Citation statistics
Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/28221
Collection	中国科学院上海硅酸盐研究所
Recommended Citation GB/T 7714	Zhang, ZWB,Dai, QX,Zhang, Y,et al. Design of a Multifunctional Biomaterial Inspired by Ancient Chinese Medicine for Hair Regeneration in Burned Skin[J]. ACS APPLIED MATERIALS & INTERFACES,2020(11):12489.
APA	Zhang, ZWB.,Dai, QX.,Zhang, Y.,Zhuang, H.,Wang, ED.,...&Chang, J.(2020).Design of a Multifunctional Biomaterial Inspired by Ancient Chinese Medicine for Hair Regeneration in Burned Skin.ACS APPLIED MATERIALS & INTERFACES(11),12489.
MLA	Zhang, ZWB,et al."Design of a Multifunctional Biomaterial Inspired by Ancient Chinese Medicine for Hair Regeneration in Burned Skin".ACS APPLIED MATERIALS & INTERFACES .11(2020):12489.

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