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Dual-targeting and excretable ultrasmall SPIONs for T-1-weighted positive MR imaging of intracranial glioblastoma cells by targeting the lipoprotein receptor-related protein
Du, CJ; Liu, XP; Hu, H; Li, HM; Yu, LD; Geng, DY; Chen, Y; Zhang, J
2020-03-21
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
Issue11Pages:2296
SubtypeArticle
AbstractA precise delineation of the intracranial glioblastoma boundary is urgently required for pre-surgical operations, due to the tumor-inherent infiltrative character of a tumor and the difficulty to completely remove the tumor. Magnetic resonance (MR) imaging is the leading clinical diagnostic tool for brain tumors, where a safe MR contrast agent that targets cancer biomarkers is critical for non-invasive and accurate brain tumor detection. In this work, a multifunctional targeted nanoprobe composed of PEGylated ultrasmall superparamagnetic iron oxide nanoparticles (USPIONs), with surface conjugated Angiopep-2, was successfully constructed by a stepwise reaction. The nanoprobe efficiently crossed the blood-brain barrier (BBB), targeted the glioblastoma and then generated positive contrast enhancement for T-1-weighted MR imaging. Angiopep-2 was herein selected as a targeting ligand to construct the dual-targeting nanoprobes for MR imaging of brain tumors, because it can specifically combine to the low-density lipoprotein receptor-related protein (LRP), which is overexpressed in both BBB and glioblastoma cells. The targeting capability and, in particular, the biocompatibility/excretion of these ANG-modified MRI nanoprobes were systematically evaluated not only at the intracellular level in vitro, but also on tumor xenografts in vivo. This first report on ANG-engineered USPIONs as T-1-weighted positive MR contrast agents for intracranial targeted glioblastoma imaging, provides a promising application potential for these SPION-based ultrasmall nanoprobes, not only for efficient pre-operative tumor diagnosis, but also for the targeted surgical resection of intracranial glioblastomas.
DOI10.1039/c9tb02391g
WOS KeywordIRON-OXIDE NANOPARTICLES ; CONTRAST AGENTS ; BRAIN GLIOMA ; DELIVERY ; TUMOR ; MONODISPERSE ; NANOPROBE ; DESIGN ; SYSTEM
Language英语
WOS Research AreaMaterials Science
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/28218
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Du, CJ,Liu, XP,Hu, H,et al. Dual-targeting and excretable ultrasmall SPIONs for T-1-weighted positive MR imaging of intracranial glioblastoma cells by targeting the lipoprotein receptor-related protein[J]. JOURNAL OF MATERIALS CHEMISTRY B,2020(11):2296.
APA Du, CJ.,Liu, XP.,Hu, H.,Li, HM.,Yu, LD.,...&Zhang, J.(2020).Dual-targeting and excretable ultrasmall SPIONs for T-1-weighted positive MR imaging of intracranial glioblastoma cells by targeting the lipoprotein receptor-related protein.JOURNAL OF MATERIALS CHEMISTRY B(11),2296.
MLA Du, CJ,et al."Dual-targeting and excretable ultrasmall SPIONs for T-1-weighted positive MR imaging of intracranial glioblastoma cells by targeting the lipoprotein receptor-related protein".JOURNAL OF MATERIALS CHEMISTRY B .11(2020):2296.
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