KMS Shanghai Institute of Ceramics，Chinese Academy of Sciences
| Dual-targeting and excretable ultrasmall SPIONs for T-1-weighted positive MR imaging of intracranial glioblastoma cells by targeting the lipoprotein receptor-related protein | |
| Du, CJ; Liu, XP; Hu, H; Li, HM; Yu, LD; Geng, DY; Chen, Y; Zhang, J | |
| 2020-03-21 | |
| Source Publication | JOURNAL OF MATERIALS CHEMISTRY B
 |
| ISSN | 2050-750X |
| Issue | 11Pages:2296 |
| Subtype | Article |
| Abstract | A precise delineation of the intracranial glioblastoma boundary is urgently required for pre-surgical operations, due to the tumor-inherent infiltrative character of a tumor and the difficulty to completely remove the tumor. Magnetic resonance (MR) imaging is the leading clinical diagnostic tool for brain tumors, where a safe MR contrast agent that targets cancer biomarkers is critical for non-invasive and accurate brain tumor detection. In this work, a multifunctional targeted nanoprobe composed of PEGylated ultrasmall superparamagnetic iron oxide nanoparticles (USPIONs), with surface conjugated Angiopep-2, was successfully constructed by a stepwise reaction. The nanoprobe efficiently crossed the blood-brain barrier (BBB), targeted the glioblastoma and then generated positive contrast enhancement for T-1-weighted MR imaging. Angiopep-2 was herein selected as a targeting ligand to construct the dual-targeting nanoprobes for MR imaging of brain tumors, because it can specifically combine to the low-density lipoprotein receptor-related protein (LRP), which is overexpressed in both BBB and glioblastoma cells. The targeting capability and, in particular, the biocompatibility/excretion of these ANG-modified MRI nanoprobes were systematically evaluated not only at the intracellular level in vitro, but also on tumor xenografts in vivo. This first report on ANG-engineered USPIONs as T-1-weighted positive MR contrast agents for intracranial targeted glioblastoma imaging, provides a promising application potential for these SPION-based ultrasmall nanoprobes, not only for efficient pre-operative tumor diagnosis, but also for the targeted surgical resection of intracranial glioblastomas. |
| DOI | 10.1039/c9tb02391g |
| WOS Keyword | IRON-OXIDE NANOPARTICLES ; CONTRAST AGENTS ; BRAIN GLIOMA ; DELIVERY ; TUMOR ; MONODISPERSE ; NANOPROBE ; DESIGN ; SYSTEM |
| Language | 英语 |
| WOS Research Area | Materials Science |
| Publisher | ROYAL SOC CHEMISTRY |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sic.ac.cn/handle/331005/28218 |
| Collection | 中国科学院上海硅酸盐研究所 |
| Recommended Citation GB/T 7714 | Du, CJ,Liu, XP,Hu, H,et al. Dual-targeting and excretable ultrasmall SPIONs for T-1-weighted positive MR imaging of intracranial glioblastoma cells by targeting the lipoprotein receptor-related protein[J]. JOURNAL OF MATERIALS CHEMISTRY B,2020(11):2296. |
| APA | Du, CJ.,Liu, XP.,Hu, H.,Li, HM.,Yu, LD.,...&Zhang, J.(2020).Dual-targeting and excretable ultrasmall SPIONs for T-1-weighted positive MR imaging of intracranial glioblastoma cells by targeting the lipoprotein receptor-related protein.JOURNAL OF MATERIALS CHEMISTRY B(11),2296. |
| MLA | Du, CJ,et al."Dual-targeting and excretable ultrasmall SPIONs for T-1-weighted positive MR imaging of intracranial glioblastoma cells by targeting the lipoprotein receptor-related protein".JOURNAL OF MATERIALS CHEMISTRY B .11(2020):2296. |
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