Full-Process Radiosensitization Based on Nanoscale Metal-Organic Frameworks
Gong, T; Li, YL; Lv, B; Wang, H; Liu, YY; Yang, W; Wu, YL; Jiang, XW; Gao, HB; Zheng, XP; Bu, WB
Source PublicationACS NANO
AbstractFull-process radiosensitization, that is, pre-increasing radiation sensitivity of cancer cells, magnifying center dot OH formation during ionizing irradiation, and intervention on the resultant DNA repair for final cells death, could enhance the overall radiotherapeutic effects, but has not yet been achieved. Herein, Hf-nMOFs with Fe3+ ions uniformly dispersed (Hf-BPY-Fe) were constructed to integratedly improve radiotherapeutic effects via a multifaceted mechanism. The in vitro experiments demonstrated that persistent reactive oxygen species stress from Hf-BPY-Fe-activated in situ Fenton reaction reassorted cell cycle distribution, consequently contributing to increased tumoral radiosensitivity to photon radiation. Upon irradiation during the course of radiation therapy, Hf4+ in Hf-BPY-Fe gave substantial amounts of high-energy electrons, which partially converted H2O to center dot OH and, meanwhile, relaxed to a low-energy state in nMOF pores, leading to an electron-rich environment. These aggregated electrons facilitated the reduction from Fe3+ to Fe2+ and further promoted the production of center dot OH in the Fenton process to attack DNA. The Hf-BPY-Fe postponed the DNA damage response process by interfering with certain proteins involved in the DNA repair signaling pathway. The in vivo experiments showed improved radiotherapeutic effects from integrated contributions from Fe3+-based Fenton reaction and Hf4+-induced X-ray energy conversion in tumors. This work provides a nMOFs-based full-process radiosensitizing approach for better radiotherapeutic efficacy.
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
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Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
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GB/T 7714
Gong, T,Li, YL,Lv, B,et al. Full-Process Radiosensitization Based on Nanoscale Metal-Organic Frameworks[J]. ACS NANO,2020(3):3032.
APA Gong, T.,Li, YL.,Lv, B.,Wang, H.,Liu, YY.,...&Bu, WB.(2020).Full-Process Radiosensitization Based on Nanoscale Metal-Organic Frameworks.ACS NANO(3),3032.
MLA Gong, T,et al."Full-Process Radiosensitization Based on Nanoscale Metal-Organic Frameworks".ACS NANO .3(2020):3032.
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