Full-Process Radiosensitization Based on Nanoscale Metal-Organic Frameworks

doi:10.1021/acsnano.9b07898

SIC OpenIR

	Full-Process Radiosensitization Based on Nanoscale Metal-Organic Frameworks
	Gong, T; Li, YL; Lv, B; Wang, H; Liu, YY; Yang, W; Wu, YL; Jiang, XW; Gao, HB; Zheng, XP; Bu, WB
	2020-03-24
Source Publication	ACS NANO
ISSN	1936-0851
Issue	3 Pages:3032
Subtype	Article
Abstract	Full-process radiosensitization, that is, pre-increasing radiation sensitivity of cancer cells, magnifying center dot OH formation during ionizing irradiation, and intervention on the resultant DNA repair for final cells death, could enhance the overall radiotherapeutic effects, but has not yet been achieved. Herein, Hf-nMOFs with Fe3+ ions uniformly dispersed (Hf-BPY-Fe) were constructed to integratedly improve radiotherapeutic effects via a multifaceted mechanism. The in vitro experiments demonstrated that persistent reactive oxygen species stress from Hf-BPY-Fe-activated in situ Fenton reaction reassorted cell cycle distribution, consequently contributing to increased tumoral radiosensitivity to photon radiation. Upon irradiation during the course of radiation therapy, Hf4+ in Hf-BPY-Fe gave substantial amounts of high-energy electrons, which partially converted H2O to center dot OH and, meanwhile, relaxed to a low-energy state in nMOF pores, leading to an electron-rich environment. These aggregated electrons facilitated the reduction from Fe3+ to Fe2+ and further promoted the production of center dot OH in the Fenton process to attack DNA. The Hf-BPY-Fe postponed the DNA damage response process by interfering with certain proteins involved in the DNA repair signaling pathway. The in vivo experiments showed improved radiotherapeutic effects from integrated contributions from Fe3+-based Fenton reaction and Hf4+-induced X-ray energy conversion in tumors. This work provides a nMOFs-based full-process radiosensitizing approach for better radiotherapeutic efficacy.
DOI	10.1021/acsnano.9b07898
WOS Keyword	RADIATION-THERAPY ; IN-VIVO ; SUSCEPTIBILITY ; WATER ; PH
Language	英语
WOS Research Area	Chemistry ; Science & Technology - Other Topics ; Materials Science
Publisher	AMER CHEMICAL SOC
Citation statistics	Cited Times:6[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/28212
Collection	中国科学院上海硅酸盐研究所
Recommended Citation GB/T 7714	Gong, T,Li, YL,Lv, B,et al. Full-Process Radiosensitization Based on Nanoscale Metal-Organic Frameworks[J]. ACS NANO,2020(3):3032.
APA	Gong, T.,Li, YL.,Lv, B.,Wang, H.,Liu, YY.,...&Bu, WB.(2020).Full-Process Radiosensitization Based on Nanoscale Metal-Organic Frameworks.ACS NANO(3),3032.
MLA	Gong, T,et al."Full-Process Radiosensitization Based on Nanoscale Metal-Organic Frameworks".ACS NANO .3(2020):3032.

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