Tumor-Specific Chemotherapy by Nanomedicine-Enabled Differential Stress Sensitization

doi:10.1002/anie.202002306

SIC OpenIR

	Tumor-Specific Chemotherapy by Nanomedicine-Enabled Differential Stress Sensitization
	Yang, BW; Chen, Y; Shi, JL
	2020-06-01
Source Publication	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN	1433-7851
Issue	24 Pages:9693
Subtype	Article
Abstract	Most of current nanomedicines are administrated intravenously to favour tumor accumulation through enhanced permeability and retention (EPR) effect, which, however, suffers from several drawbacks such as low drug bioavailability and severe side effect. In this work, we have constructed a doxorubicin(Dox)-based liposomal nanosystem for tumor-specific chemotherapy, by enabling differential stress sensitization between cancer and normal cells for restricting the chemodrug toxicity exclusively in tumor regions. 2-Deoxy-D-glucose (2DG) was loaded in the nanoliposome to inhibit glycolysis of cancer cells, which works in synergy with the co-loaded chemodrug Dox to promote mitochondrial depolarization and subsequent apoptosis. In addition, the starvation effect of 2DG can counteract the toxicity of Dox in normal cells and thus mitigates the harmful side effect of chemotherapy. It is expected that such a differential stress sensitization strategy may greatly benefit future nanomedicine design.
DOI	10.1002/anie.202002306
WOS Keyword	MOLECULAR-MECHANISMS ; CANCER ; MITOCHONDRIA ; METABOLISM ; DOXORUBICIN ; CARCINOMA ; LIPOSOME ; TIME
Language	英语
WOS Research Area	Chemistry
Publisher	WILEY-V C H VERLAG GMBH
Citation statistics	Cited Times:8[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/28179
Collection	中国科学院上海硅酸盐研究所
Recommended Citation GB/T 7714	Yang, BW,Chen, Y,Shi, JL. Tumor-Specific Chemotherapy by Nanomedicine-Enabled Differential Stress Sensitization[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020(24):9693.
APA	Yang, BW,Chen, Y,&Shi, JL.(2020).Tumor-Specific Chemotherapy by Nanomedicine-Enabled Differential Stress Sensitization.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION(24),9693.
MLA	Yang, BW,et al."Tumor-Specific Chemotherapy by Nanomedicine-Enabled Differential Stress Sensitization".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION .24(2020):9693.

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