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Tumor-Specific Chemotherapy by Nanomedicine-Enabled Differential Stress Sensitization
Yang, BW; Chen, Y; Shi, JL
2020-06-01
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
Issue24Pages:9693
SubtypeArticle
AbstractMost of current nanomedicines are administrated intravenously to favour tumor accumulation through enhanced permeability and retention (EPR) effect, which, however, suffers from several drawbacks such as low drug bioavailability and severe side effect. In this work, we have constructed a doxorubicin(Dox)-based liposomal nanosystem for tumor-specific chemotherapy, by enabling differential stress sensitization between cancer and normal cells for restricting the chemodrug toxicity exclusively in tumor regions. 2-Deoxy-D-glucose (2DG) was loaded in the nanoliposome to inhibit glycolysis of cancer cells, which works in synergy with the co-loaded chemodrug Dox to promote mitochondrial depolarization and subsequent apoptosis. In addition, the starvation effect of 2DG can counteract the toxicity of Dox in normal cells and thus mitigates the harmful side effect of chemotherapy. It is expected that such a differential stress sensitization strategy may greatly benefit future nanomedicine design.
DOI10.1002/anie.202002306
WOS KeywordMOLECULAR-MECHANISMS ; CANCER ; MITOCHONDRIA ; METABOLISM ; DOXORUBICIN ; CARCINOMA ; LIPOSOME ; TIME
Language英语
WOS Research AreaChemistry
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/28179
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Yang, BW,Chen, Y,Shi, JL. Tumor-Specific Chemotherapy by Nanomedicine-Enabled Differential Stress Sensitization[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020(24):9693.
APA Yang, BW,Chen, Y,&Shi, JL.(2020).Tumor-Specific Chemotherapy by Nanomedicine-Enabled Differential Stress Sensitization.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION(24),9693.
MLA Yang, BW,et al."Tumor-Specific Chemotherapy by Nanomedicine-Enabled Differential Stress Sensitization".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION .24(2020):9693.
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