KMS Shanghai Institute of Ceramics，Chinese Academy of Sciences
| Reconstructing the intracellular pH microenvironment for enhancing photodynamic therapy | |
| Wang, CC; Zhao, PR; Yang, GL; Chen, XY; Jiang, YQ; Jiang, XW; Wu, YL; Liu, YY; Zhang, WA; Bu, WB | |
| 2020-04-01 | |
| Source Publication | MATERIALS HORIZONS
 |
| ISSN | 2051-6347 |
| Issue | 4Pages:1180 |
| Subtype | Article |
| Abstract | Acidic tumor microenvironments, characterized by weak acidity outside the cell (pH similar to 6.5-7.0), have been revealed as a potential therapeutic target with specific acid-responsible materials. However, the intracellular pH of tumor cells is still slightly alkaline (pH similar to 7.2-7.4), which is not conducive for nanomaterials that respond to acid but should destroy intracellular substances. Here, we proposed a new strategy for reconstructing the intracellular pH microenvironment to enhance photodynamic therapy. Nanomaterials (UCNP@ZIF + TPP + PA) were designed with an NaYF4:Yb:Tm (UCNP) inner core coated by a porous zeolitic imidazolate framework (ZIF-8) outside for photoacid (PA) and acid-responsive porphyrin (TPP) co-loading. Upon 980 nm laser irradiation, the emission light of UCNP activates PA for H+ release, which achieves reconstruction of the intracellular pH environment. In this new acid condition, TPP becomes protonated (TPP-H+), which reduces its aggregation by enhancing its water solubility, and in turn increases singlet oxygen (O-1(2)) production for enhanced tumor killing. Both in vitro and in vivo experiments have proved that UCNP@ZIF + TPP + PA could reconstruct the intracellular pH environment and enhance therapeutic effect of photodynamic therapy (PDT). Reconstructing the intracellular pH by using light is of great significance for acid-responsive nanosystems to destroy intracellular substances and treat tumors. The results also signify the use of such acid-responsive materials for several other disease therapies. |
| DOI | 10.1039/c9mh01824g |
| WOS Keyword | NANOPARTICLES ; OXYGEN |
| Language | 英语 |
| WOS Research Area | Chemistry ; Materials Science |
| Publisher | ROYAL SOC CHEMISTRY |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sic.ac.cn/handle/331005/28174 |
| Collection | 中国科学院上海硅酸盐研究所 |
| Recommended Citation GB/T 7714 | Wang, CC,Zhao, PR,Yang, GL,et al. Reconstructing the intracellular pH microenvironment for enhancing photodynamic therapy[J]. MATERIALS HORIZONS,2020(4):1180. |
| APA | Wang, CC.,Zhao, PR.,Yang, GL.,Chen, XY.,Jiang, YQ.,...&Bu, WB.(2020).Reconstructing the intracellular pH microenvironment for enhancing photodynamic therapy.MATERIALS HORIZONS(4),1180. |
| MLA | Wang, CC,et al."Reconstructing the intracellular pH microenvironment for enhancing photodynamic therapy".MATERIALS HORIZONS .4(2020):1180. |
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