Radionuclide-labeled gold nanoparticles for nuclei-targeting internal radio-immunity therapy

doi:10.1039/c9mh01725a

SIC OpenIR

	Radionuclide-labeled gold nanoparticles for nuclei-targeting internal radio-immunity therapy
	Su, WW; Chen, C; Wang, T; Li, X; Liu, YY; Wang, H; Zhao, S; Zuo, CJ; Sun, GF; Bu, WB
	2020-04-01
Source Publication	MATERIALS HORIZONS
ISSN	2051-6347
Issue	4 Pages:1115
Subtype	Article
Abstract	Radionuclide therapy is an important form of tumor internal radiation therapy (IRT), but its curative effect is restricted by the low radiation intensity and poor targeting ability of nuclides, which hampers efficient killing of DNA. Moreover, the limited penetration depth and nonuniform dose distribution of rays result in "blind" regions with residual living cancer cells, which increases the risk of tumor metastasis. Herein, we developed a new strategy to tactfully incorporate IRT with immunotherapy to achieve highly efficient synergistic therapy. Specifically, gold nanoparticles (AuNPs) co-modified with radioactive iodine-131 and the twin arginine translocation (TAT) peptide (I-131-AuNPs-TAT) were constructed, in which TAT-guided nuclei targeting provided highly concentrated beta-rays to the most radiosensitive DNA. Meanwhile, beta(-) electrons dashed on AuNPs with a sudden drop in speed can transform into low-dosage X-ray bremsstrahlung radiation. X-rays have a longer penetration depth than beta-rays and are able to induce a strong immune response, thus eliminating the area that is blind to short-range beta-rays resulting from the limited dose distribution. This method, named "internal radio-immunity therapy (IRIT)", is a unique approach that combines IRT with immunotherapy to not only enhance radiotherapeutic efficacy but also broaden the clinical applications of I-131, thereby demonstrating great potential for scientific research and clinical applications.
DOI	10.1039/c9mh01725a
WOS Keyword	DOUBLE-STRAND BREAKS ; MACROPHAGE DIFFERENTIATION ; MOLECULAR MARKER ; T-CELL ; GAMMA-H2AX ; IRRADIATION ; INHIBITION ; ANTITUMOR ; DELIVERY ; DAMAGE
Language	英语
WOS Research Area	Chemistry ; Materials Science
Publisher	ROYAL SOC CHEMISTRY
Citation statistics
Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/28173
Collection	中国科学院上海硅酸盐研究所
Recommended Citation GB/T 7714	Su, WW,Chen, C,Wang, T,et al. Radionuclide-labeled gold nanoparticles for nuclei-targeting internal radio-immunity therapy[J]. MATERIALS HORIZONS,2020(4):1115.
APA	Su, WW.,Chen, C.,Wang, T.,Li, X.,Liu, YY.,...&Bu, WB.(2020).Radionuclide-labeled gold nanoparticles for nuclei-targeting internal radio-immunity therapy.MATERIALS HORIZONS(4),1115.
MLA	Su, WW,et al."Radionuclide-labeled gold nanoparticles for nuclei-targeting internal radio-immunity therapy".MATERIALS HORIZONS .4(2020):1115.

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