SIC OpenIR
Radionuclide-labeled gold nanoparticles for nuclei-targeting internal radio-immunity therapy
Su, WW; Chen, C; Wang, T; Li, X; Liu, YY; Wang, H; Zhao, S; Zuo, CJ; Sun, GF; Bu, WB
2020-04-01
Source PublicationMATERIALS HORIZONS
ISSN2051-6347
Issue4Pages:1115
SubtypeArticle
AbstractRadionuclide therapy is an important form of tumor internal radiation therapy (IRT), but its curative effect is restricted by the low radiation intensity and poor targeting ability of nuclides, which hampers efficient killing of DNA. Moreover, the limited penetration depth and nonuniform dose distribution of rays result in "blind" regions with residual living cancer cells, which increases the risk of tumor metastasis. Herein, we developed a new strategy to tactfully incorporate IRT with immunotherapy to achieve highly efficient synergistic therapy. Specifically, gold nanoparticles (AuNPs) co-modified with radioactive iodine-131 and the twin arginine translocation (TAT) peptide (I-131-AuNPs-TAT) were constructed, in which TAT-guided nuclei targeting provided highly concentrated beta-rays to the most radiosensitive DNA. Meanwhile, beta(-) electrons dashed on AuNPs with a sudden drop in speed can transform into low-dosage X-ray bremsstrahlung radiation. X-rays have a longer penetration depth than beta-rays and are able to induce a strong immune response, thus eliminating the area that is blind to short-range beta-rays resulting from the limited dose distribution. This method, named "internal radio-immunity therapy (IRIT)", is a unique approach that combines IRT with immunotherapy to not only enhance radiotherapeutic efficacy but also broaden the clinical applications of I-131, thereby demonstrating great potential for scientific research and clinical applications.
DOI10.1039/c9mh01725a
WOS KeywordDOUBLE-STRAND BREAKS ; MACROPHAGE DIFFERENTIATION ; MOLECULAR MARKER ; T-CELL ; GAMMA-H2AX ; IRRADIATION ; INHIBITION ; ANTITUMOR ; DELIVERY ; DAMAGE
Language英语
WOS Research AreaChemistry ; Materials Science
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/28173
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Su, WW,Chen, C,Wang, T,et al. Radionuclide-labeled gold nanoparticles for nuclei-targeting internal radio-immunity therapy[J]. MATERIALS HORIZONS,2020(4):1115.
APA Su, WW.,Chen, C.,Wang, T.,Li, X.,Liu, YY.,...&Bu, WB.(2020).Radionuclide-labeled gold nanoparticles for nuclei-targeting internal radio-immunity therapy.MATERIALS HORIZONS(4),1115.
MLA Su, WW,et al."Radionuclide-labeled gold nanoparticles for nuclei-targeting internal radio-immunity therapy".MATERIALS HORIZONS .4(2020):1115.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Su, WW]'s Articles
[Chen, C]'s Articles
[Wang, T]'s Articles
Baidu academic
Similar articles in Baidu academic
[Su, WW]'s Articles
[Chen, C]'s Articles
[Wang, T]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Su, WW]'s Articles
[Chen, C]'s Articles
[Wang, T]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.