SIC OpenIR
A highly sensitive and selective nanosensor for near-infrared potassium imaging
Liu, JN; Pan, LM; Shang, CF; Lu, B; Wu, RJ; Feng, Y; Chen, WY; Zhang, RW; Bu, JW; Xiong, ZQ; Bu, WB; Du, JL; Shi, JL
2020-04-01
Source PublicationSCIENCE ADVANCES
ISSN2375-2548
Issue16
SubtypeArticle
AbstractPotassium ion (K+) concentration fluctuates in various biological processes. A number of r probes have been developed to monitor such fluctuations through optical imaging. However, the currently available r probes are far from being sensitive enough in detecting physiological fluctuations in living animals. Furthermore, the monitoring of deep tissues is not applicable because of short-wavelength excitation prevailingly used so far. Here, we report a highly sensitive and selective nanosensor for near-infrared (NIR) K+ imaging in living cells and animals. The nanosensor is constructed by encapsulating upconversion nanoparticles (UCNPs) and a commercial K+ indicator in the hollow cavity of mesoporous silica nanoparticles, followed by coating a K+ -selective filter membrane. The membrane adsorbs r from the medium and filters out interfering cations. The UCNPs convert NIR to ultraviolet light, which excites the r indicator, thus allowing the detection of the fluctuations of K+ concentration in cultured cells and intact mouse brains.
DOI10.1126/sciadv.aax9757
WOS KeywordUP-CONVERSION NANOPARTICLES ; IN-VIVO ; NANOCRYSTALS ; RESONANCE ; CHANNELS ; SENSOR
Language英语
WOS Research AreaScience & Technology - Other Topics
PublisherAMER ASSOC ADVANCEMENT SCIENCE
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/28165
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Liu, JN,Pan, LM,Shang, CF,et al. A highly sensitive and selective nanosensor for near-infrared potassium imaging[J]. SCIENCE ADVANCES,2020(16).
APA Liu, JN.,Pan, LM.,Shang, CF.,Lu, B.,Wu, RJ.,...&Shi, JL.(2020).A highly sensitive and selective nanosensor for near-infrared potassium imaging.SCIENCE ADVANCES(16).
MLA Liu, JN,et al."A highly sensitive and selective nanosensor for near-infrared potassium imaging".SCIENCE ADVANCES .16(2020).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Liu, JN]'s Articles
[Pan, LM]'s Articles
[Shang, CF]'s Articles
Baidu academic
Similar articles in Baidu academic
[Liu, JN]'s Articles
[Pan, LM]'s Articles
[Shang, CF]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Liu, JN]'s Articles
[Pan, LM]'s Articles
[Shang, CF]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.