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3D printing of hydrogels: Rational design strategies and emerging biomedical applications
Li, JH; Wu, CT; Chu, PK; Gelinsky, M
2020-04-01
Source PublicationMATERIALS SCIENCE & ENGINEERING R-REPORTS
ISSN0927-796X
SubtypeReview
Abstract3D printing alias additive manufacturing can transform 3D virtual models created by computer-aided design (CAD) into physical 3D objects in a layer-by-layer manner dispensing with conventional molding or machining. Since the incipiency, significant advancements have been achieved in understanding the process of 3D printing and the relationship of component, structure, property and application of the created objects. Because hydrogels are one of the most feasible classes of ink materials for 3D printing and this field has been rapidly advancing, this Review focuses on hydrogel designs and development of advanced hydrogel-based biomaterial inks and bioinks for 3D printing. It covers 3D printing techniques including laser printing (stereolithography, two-photon polymerization), extrusion printing (3D plotting, direct ink writing), inkjet printing, 3D bioprinting, 4D printing and 4D bioprinting. It provides a comprehensive overview and discussion of the tailorability of material, mechanical, physical, chemical and biological properties of hydrogels to enable advanced hydrogel designs for 3D printing. The range of hydrogel-forming polymers covered encompasses biopolymers, synthetic polymers, polymer blends, nanocomposites, functional polymers, and cell-laden systems. The representative biomedical applications selected demonstrate how hydrogel-based 3D printing is being exploited in tissue engineering, regenerative medicine, cancer research, in vitro disease modeling, high-throughput drug screening, surgical preparation, soft robotics and flexible wearable electronics. Incomparable by thermoplastics, thermosets, ceramics and metals, hydrogel-based 3D printing is playing a pivotal role in the design and creation of advanced functional (bio) systems in a customizable way. An outlook on future directions of hydrogel-based 3D printing is presented.
DOI10.1016/j.mser.2020.100543
WOS KeywordHYALURONIC-ACID HYDROGEL ; MESENCHYMAL STEM-CELLS ; GELLAN-GUM HYDROGELS ; POLY(VINYL ALCOHOL) HYDROGELS ; DOUBLE-NETWORK HYDROGELS ; RECOMBINANT SPIDER SILK ; POLY(ETHYLENE GLYCOL) HYDROGEL ; OF-THE-ART ; BIODEGRADABLE DEXTRAN HYDROGELS ; KAPPA-CARRAGEENAN HYDROGEL
Language英语
WOS Research AreaMaterials Science ; Physics
PublisherELSEVIER SCIENCE SA
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/28163
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Li, JH,Wu, CT,Chu, PK,et al. 3D printing of hydrogels: Rational design strategies and emerging biomedical applications[J]. MATERIALS SCIENCE & ENGINEERING R-REPORTS,2020.
APA Li, JH,Wu, CT,Chu, PK,&Gelinsky, M.(2020).3D printing of hydrogels: Rational design strategies and emerging biomedical applications.MATERIALS SCIENCE & ENGINEERING R-REPORTS.
MLA Li, JH,et al."3D printing of hydrogels: Rational design strategies and emerging biomedical applications".MATERIALS SCIENCE & ENGINEERING R-REPORTS (2020).
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