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Auger Electrons Constructed Active Sites on Nanocatalysts for Catalytic Internal Radiotherapy
Su, WW; Wang, H; Wang, T; Li, X; Tang, ZM; Zhao, S; Zhang, M; Li, DN; Jiang, XW; Gong, T; Yang, W; Zuo, CJ; Wu, YL; Bu, WB
2020-05-01
Source PublicationADVANCED SCIENCE
Issue10
SubtypeArticle
AbstractExcess electrons play important roles for the construction of superficial active sites on nanocatalysts. However, providing excess electrons to nanocatalysts in vivo is still a challenge, which limits the applications of nanocatalysts in biomedicine. Herein, auger electrons (AEs) emitted from radionuclide 125 (I-125) are used in situ to construct active sites in a nanocatalyst (TiO2) and the application of this method is further extended to cancer catalytic internal radiotherapy (CIRT). The obtained I-125-TiO2 nanoparticles first construct superficial Ti3+ active sites via the reaction between Ti4+ and AEs. Then Ti3+ stretches and weakens the O-H bond of the absorbed H2O, thus enhancing the radiolysis of H2O molecules and generating hydroxyl radicals (center dot OH). All in vitro and in vivo results demonstrate a good CIRT performance. These findings will broaden the application of radionuclides and introduce new perspectives to nanomedicine.
DOI10.1002/advs.201903585
WOS KeywordIONIZING-RADIATION ; SEED IMPLANTATION ; BRACHYTHERAPY ; NANOPARTICLES ; SCINTILLATOR ; INDUCTION ; CRYSTALS ; SURFACES ; THERAPY ; DNA
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
PublisherWILEY
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/28151
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Su, WW,Wang, H,Wang, T,et al. Auger Electrons Constructed Active Sites on Nanocatalysts for Catalytic Internal Radiotherapy[J]. ADVANCED SCIENCE,2020(10).
APA Su, WW.,Wang, H.,Wang, T.,Li, X.,Tang, ZM.,...&Bu, WB.(2020).Auger Electrons Constructed Active Sites on Nanocatalysts for Catalytic Internal Radiotherapy.ADVANCED SCIENCE(10).
MLA Su, WW,et al."Auger Electrons Constructed Active Sites on Nanocatalysts for Catalytic Internal Radiotherapy".ADVANCED SCIENCE .10(2020).
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