Accurate and Real-Time Temperature Monitoring during MR Imaging Guided PTT

doi:10.1021/acs.nanolett.9b05267

SIC OpenIR

	Accurate and Real-Time Temperature Monitoring during MR Imaging Guided PTT
	Meng, XF; Zhang, BY; Yi, Y; Cheng, H; Wang, BM; Liu, YY; Gong, T; Yang, W; Yao, YF; Wang, H; Bu, WB
	2020-04-08
Source Publication	NANO LETTERS
ISSN	1530-6984
Issue	4 Pages:2522
Subtype	Article
Abstract	Photothermal therapy (PTT) is an efficient approach for cancer treatment. However, accurately monitoring the spatial distribution of photothermal transducing agents (PTAs) and mapping the real-time temperature change in tumor and peritumoral normal tissue remain a huge challenge. Here, we propose an innovative strategy to integrate T-1-MRI for precisely tracking PTAs with magnetic resonance temperature imaging (MRTI) for real-time monitoring temperature change in vivo during PTT. NaBiF4: Gd@PDA@PEG nanomaterials were synthesized with favorable T-1-weighted performance to target tumor and localize PTAs. The extremely weak susceptibility (1.04 X 10(-6) emu g(-1)Oe(1-)) of NaBiF4: Gd@PDA@PEG interferes with the local phase marginally, which maintains the capability of MRTI to dynamically record real-time temperature change in tumor and peritumoral normal tissue. The time resolution is 19 s per frame, and the detection precision of temperature change is approximately 0.1 K. The approach achieving PTT guided by multimode MRI holds significant potential for the clinical application.
DOI	10.1021/acs.nanolett.9b05267
WOS Keyword	PHOTOTHERMAL THERAPY ; CANCER ; THERMOMETRY ; NANOPARTICLES ; NANOMATERIALS ; HYPERTHERMIA ; GRAPHENE ; TISSUE ; OXIDE
Language	英语
WOS Research Area	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
Publisher	AMER CHEMICAL SOC
Citation statistics
Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/28150
Collection	中国科学院上海硅酸盐研究所
Recommended Citation GB/T 7714	Meng, XF,Zhang, BY,Yi, Y,et al. Accurate and Real-Time Temperature Monitoring during MR Imaging Guided PTT[J]. NANO LETTERS,2020(4):2522.
APA	Meng, XF.,Zhang, BY.,Yi, Y.,Cheng, H.,Wang, BM.,...&Bu, WB.(2020).Accurate and Real-Time Temperature Monitoring during MR Imaging Guided PTT.NANO LETTERS(4),2522.
MLA	Meng, XF,et al."Accurate and Real-Time Temperature Monitoring during MR Imaging Guided PTT".NANO LETTERS .4(2020):2522.

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