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Accurate and Real-Time Temperature Monitoring during MR Imaging Guided PTT
Meng, XF; Zhang, BY; Yi, Y; Cheng, H; Wang, BM; Liu, YY; Gong, T; Yang, W; Yao, YF; Wang, H; Bu, WB
2020-04-08
Source PublicationNANO LETTERS
ISSN1530-6984
Issue4Pages:2522
SubtypeArticle
AbstractPhotothermal therapy (PTT) is an efficient approach for cancer treatment. However, accurately monitoring the spatial distribution of photothermal transducing agents (PTAs) and mapping the real-time temperature change in tumor and peritumoral normal tissue remain a huge challenge. Here, we propose an innovative strategy to integrate T-1-MRI for precisely tracking PTAs with magnetic resonance temperature imaging (MRTI) for real-time monitoring temperature change in vivo during PTT. NaBiF4: Gd@PDA@PEG nanomaterials were synthesized with favorable T-1-weighted performance to target tumor and localize PTAs. The extremely weak susceptibility (1.04 X 10(-6) emu g(-1)Oe(1-)) of NaBiF4: Gd@PDA@PEG interferes with the local phase marginally, which maintains the capability of MRTI to dynamically record real-time temperature change in tumor and peritumoral normal tissue. The time resolution is 19 s per frame, and the detection precision of temperature change is approximately 0.1 K. The approach achieving PTT guided by multimode MRI holds significant potential for the clinical application.
DOI10.1021/acs.nanolett.9b05267
WOS KeywordPHOTOTHERMAL THERAPY ; CANCER ; THERMOMETRY ; NANOPARTICLES ; NANOMATERIALS ; HYPERTHERMIA ; GRAPHENE ; TISSUE ; OXIDE
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
PublisherAMER CHEMICAL SOC
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Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/28150
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Meng, XF,Zhang, BY,Yi, Y,et al. Accurate and Real-Time Temperature Monitoring during MR Imaging Guided PTT[J]. NANO LETTERS,2020(4):2522.
APA Meng, XF.,Zhang, BY.,Yi, Y.,Cheng, H.,Wang, BM.,...&Bu, WB.(2020).Accurate and Real-Time Temperature Monitoring during MR Imaging Guided PTT.NANO LETTERS(4),2522.
MLA Meng, XF,et al."Accurate and Real-Time Temperature Monitoring during MR Imaging Guided PTT".NANO LETTERS .4(2020):2522.
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