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Defect engineering of 2D BiOCl nanosheets for photonic tumor ablation
Dai, C; Hu, RZ; Wang, CM; Liu, Z; Zhang, SJ; Yu, LD; Chen, Y; Zhang, B
2020-05-01
Source PublicationNANOSCALE HORIZONS
ISSN2055-6756
Issue5Pages:857
SubtypeArticle
AbstractPhotothermal therapy (PTT) is an emerging technology as a noninvasive therapeutic modality for inducing photonic cancer hyperthermia. However, current photothermal conversion agents suffer from low therapeutic efficiency and single functionality. Engineering crystal defects on the surface or substrate of semiconductors can substantially enhance their optical absorption capability as well as improve their photothermal effects in theranostic nanomedicines. In this study, a specific defect engineering strategy was developed to endow two-dimensional (2D) BiOCl nanosheets with intriguing photothermal conversion performance by creating oxygen vacancies on the surface (O-BiOCl). Importantly, the photothermal performance and photoacoustic imaging capability of the 2D O-BiOCl nanosheets could be precisely controlled by modulating the amounts of oxygen vacancies. The strong Bi-based X-ray attenuation coefficient endowed these nanosheets with the contrast-enhanced computed tomography imaging capability. The high near-infrared-triggered photonic hyperthermia for tumor ablation was systematically demonstrated both in vitro at the cellular level and in vivo for tumor breast cancer mice xenograft models. Based on the demonstrated high biocompatibility of these 2D O-BiOCl nanosheets, this work not only formulates an intriguing 2D photothermal nanoagent for tumor ablation, but also provides an efficient strategy to control the photothermal performance of nanoagents by defect engineering.
DOI10.1039/c9nh00707e
WOS KeywordPHOTOCATALYTIC ACTIVITY ; PHOTOTHERMAL THERAPY ; GOLD NANOPARTICLES ; OXYGEN VACANCIES ; LIGHT ; GRAPHENE ; ABSORPTION ; ACTIVATION ; MXENES
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/28091
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Dai, C,Hu, RZ,Wang, CM,et al. Defect engineering of 2D BiOCl nanosheets for photonic tumor ablation[J]. NANOSCALE HORIZONS,2020(5):857.
APA Dai, C.,Hu, RZ.,Wang, CM.,Liu, Z.,Zhang, SJ.,...&Zhang, B.(2020).Defect engineering of 2D BiOCl nanosheets for photonic tumor ablation.NANOSCALE HORIZONS(5),857.
MLA Dai, C,et al."Defect engineering of 2D BiOCl nanosheets for photonic tumor ablation".NANOSCALE HORIZONS .5(2020):857.
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