SIC OpenIR
Efficient Gene Therapy of Pancreatic Cancer via a Peptide Nucleic Acid (PNA)-Loaded Layered Double Hydroxides (LDH) Nanoplatform
Yu, ZG; Hu, P; Xu, YY; Bao, QQ; Ni, DL; Wei, CY; Shi, JL
2020-06-01
Source PublicationSMALL
ISSN1613-6810
Issue23
SubtypeArticle
AbstractPancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignant tumors with extremely poor prognosis due to the later stage diagnosis when surgical resection is no longer applicable. Alternatively, the traditional gene therapy which drives pancreatic cancer cells into an inactive state and inhibiting the proliferation and metastasis, presents potentials to safely inhibit pancreatic cancer progression, but unfortunately has received limited success to date. Here, an efficient gene therapy of pancreatic cancer is shown via a peptide nucleic acid (PNA)-loaded layered double hydroxides (LDHs) nanoplatform. Compared with the traditional DNA- or RNA-based gene therapies, the gene therapy using PNA features great advantages in recognizing and hybridizing with the target mutant sequences to form PNA-DNA hybrids with significantly enhanced stability due to the absence of electrostatic repulsion, and the constrained flexibility of the polyamide backbone. Moreover, ultrasmall LDHs are engineered to load PNA and the obtained PNA-loaded LDH platform (LDHs/PNA) is capable of efficiently and selectively targeting the intranuclear mutant sequences thanks to the proton sponge effect. Treatments with LDHs/PNA demonstrate markedly inhibited growth of pancreatic cancer xenografts via a cancer cell proliferation suppression mechanism. The results demonstrate the great potentials of LDHs/PNA as a highly promising gene therapy agent for PDAC.
DOI10.1002/smll.201907233
WOS KeywordONCOGENIC KRAS ; DNA ; NANOPARTICLES ; DELIVERY ; CELLS ; LOCALIZATION ; METASTASIS ; FACILE
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/28072
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Yu, ZG,Hu, P,Xu, YY,et al. Efficient Gene Therapy of Pancreatic Cancer via a Peptide Nucleic Acid (PNA)-Loaded Layered Double Hydroxides (LDH) Nanoplatform[J]. SMALL,2020(23).
APA Yu, ZG.,Hu, P.,Xu, YY.,Bao, QQ.,Ni, DL.,...&Shi, JL.(2020).Efficient Gene Therapy of Pancreatic Cancer via a Peptide Nucleic Acid (PNA)-Loaded Layered Double Hydroxides (LDH) Nanoplatform.SMALL(23).
MLA Yu, ZG,et al."Efficient Gene Therapy of Pancreatic Cancer via a Peptide Nucleic Acid (PNA)-Loaded Layered Double Hydroxides (LDH) Nanoplatform".SMALL .23(2020).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yu, ZG]'s Articles
[Hu, P]'s Articles
[Xu, YY]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yu, ZG]'s Articles
[Hu, P]'s Articles
[Xu, YY]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yu, ZG]'s Articles
[Hu, P]'s Articles
[Xu, YY]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.