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A selective and sensitive fluorescent probe for bilirubin in human serum based on europium(III) post-functionalized Zr(IV)-Based MOFs
Xia, C; Xu, Y; Cao, MM; Liu, YP; Xia, JF; Jiang, DY; Zhou, GH; Xie, RJ; Zhang, DF; Li, HL
2020-05-15
Source PublicationTALANTA
ISSN0039-9140
SubtypeArticle
AbstractIn the present study, a kind of Eu(III) post-functionalized Zr(IV)-based metal-organic framework (UiO-66(COOH)(2), Zr-MOF: Eu3+) was synthesized and utilized as an independently luminescent probe for sensing bilirubin (BR) in human serum, a biomarker of jaundice hepatitis. It can be served as a turn-off fluorescent switch for BR because its red emission from Eu3+ can be easily quenched by BR through a fluorescent resonant energy transfer (FRET) process between BR and its ligands, and as a result, BR is recognized successfully. Particularly, Zr-MOF: Eu3+ has shown many appealing properties, such as high sensitivity, quick response (less than 1 min), broad response window (0-15 mu M), and excellent selectivity. Most importantly, a kind of portable test paper based on Zr-MOF: Eu3+ probe has been developed for directly assessing the level of BR in real human serum and further diagnosing bilirubin-related diseases via visually observing the luminescent color variation.
DOI10.1016/j.talanta.2020.120795
WOS KeywordMETAL-ORGANIC FRAMEWORK ; GOLD NANOCLUSTERS ; CARBON DOTS ; SENSOR ; FRET ; EMISSION ; DEFECTS ; CENTERS ; UIO-66 ; OXIDE
Language英语
WOS Research AreaChemistry
PublisherELSEVIER
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/28067
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Xia, C,Xu, Y,Cao, MM,et al. A selective and sensitive fluorescent probe for bilirubin in human serum based on europium(III) post-functionalized Zr(IV)-Based MOFs[J]. TALANTA,2020.
APA Xia, C.,Xu, Y.,Cao, MM.,Liu, YP.,Xia, JF.,...&Li, HL.(2020).A selective and sensitive fluorescent probe for bilirubin in human serum based on europium(III) post-functionalized Zr(IV)-Based MOFs.TALANTA.
MLA Xia, C,et al."A selective and sensitive fluorescent probe for bilirubin in human serum based on europium(III) post-functionalized Zr(IV)-Based MOFs".TALANTA (2020).
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