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Preparation and characterization of antibacterial dopamine-functionalized reduced graphene oxide/PLLA composite nanofibers
Li, BY; Xiong, F; Yao, B; Du, Q; Cao, J; Qu, JG; Feng, W; Yuan, HH
2020-05-18
Source PublicationRSC ADVANCES
Issue32Pages:18614
SubtypeArticle
AbstractElectrospun poly(l)-lactide (PLLA) ultrafine fibers are a biodegradable and biocompatible scaffold, widely used in tissue engineering applications. Unfortunately, these scaffolds have some limitations related to the absence of bioactivity and antibacterial capacity. In this study, dopamine-functionalized reduced graphene oxide (rGO)/PLLA composite nanofibers were fabricated via electrospinning. The morphology and the physicochemical and biological properties of the composite nanofibers were investigated. The results indicate that incorporating rGO improves the hydrophilic, mechanical, and biocompatibility properties of PLLA nanofibers. Tetracycline hydrochloride (TC)-loaded rGO/PLLA composite nanofibers showed better controlled drug release profiles compared to GO/PLLA and PLLA nanofibrous scaffolds. Drug-loaded nanofibrous scaffolds showed significantly improved antibacterial activity against Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus). Additionally, rGO/PLLA composite nanofibers exhibited enhanced cytocompatibility. Thus, it can be concluded that rGO/PLLA composite nanofibers allow the development of multifunctional scaffolds for use in biomedical applications.
DOI10.1039/d0ra03224g
WOS KeywordMESENCHYMAL STEM-CELLS ; DRUG-DELIVERY ; SILVER-NANOPARTICLE ; POLYMER NANOFIBERS ; ELECTROSPUN ; POLY(L-LACTIDE) ; BIOCOMPATIBILITY ; DIFFERENTIATION ; FIBERS
Language英语
WOS Research AreaChemistry
PublisherROYAL SOC CHEMISTRY
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Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/28055
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Li, BY,Xiong, F,Yao, B,et al. Preparation and characterization of antibacterial dopamine-functionalized reduced graphene oxide/PLLA composite nanofibers[J]. RSC ADVANCES,2020(32):18614.
APA Li, BY.,Xiong, F.,Yao, B.,Du, Q.,Cao, J.,...&Yuan, HH.(2020).Preparation and characterization of antibacterial dopamine-functionalized reduced graphene oxide/PLLA composite nanofibers.RSC ADVANCES(32),18614.
MLA Li, BY,et al."Preparation and characterization of antibacterial dopamine-functionalized reduced graphene oxide/PLLA composite nanofibers".RSC ADVANCES .32(2020):18614.
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