KMS Shanghai Institute of Ceramics，Chinese Academy of Sciences
| Mesoporous bioactive glass for synergistic therapy of tumor and regeneration of bone tissue | |
| Liu, YQ; Lin, RC; Ma, LL; Zhuang, H; Feng, C; Chang, J; Wu, CT | |
| 2020-06-02 | |
| Source Publication | APPLIED MATERIALS TODAY
 |
| ISSN | 2352-9407 |
| Subtype | Article |
| Abstract | Treatment of tumorous bone defects needs complete elimination of residual cancer cells and, at the same time promotion of bone regeneration. Herein, manganese (Mn)-doped mesoporous bioactive glass-loaded with chlorine e6 (Mn-MBG/Ce6) can serve as a near-infrared (NIR) light-triggered pho-totherapy reagent for bone tumor treatment and bone regeneration. The Mn-MBG was synthesized by an evaporation-induced self-assembly (EISA) process. The addition of Mn to MBG imparted the controlled photothermal performance to Mn-MBG, but maintained well-ordered mesopores. After loading Ce6 into the ordered mesopore channel of 5Mn-MBG, the 5Mn-MBG/Ce6 displayed controlled NIR light-triggered Ce6 release. Furthermore, the mild hyperthermia induced by 5Mn-MBG/Ce6 facilitated the cellular uptake of Ce6, which significantly enhanced the efficiency of photodynamic therapy, and at the same time achieved a synergistic therapeutic effect in bone tumor therapy in vitro and in vivo . Moreover, even after short term of synergistic photodynamic and photothermal therapy, such 5Mn-MBG/Ce6 exhibited good biocompatibility and could help long term of bone tissue regeneration in vivo . Therefore, 5Mn-MBG/Ce6 could be used for ablating the residual tumor cells after surgery, and accelerating bone regeneration simultaneously, indicating a smart nanoplatform by combining photothermal/photodynamic therapy, nanomedicine delivery, and bone-forming bioactivity for treatment of tumorous bone defects. (C) 2020 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.apmt.2020.100578 |
| WOS Keyword | PHOTODYNAMIC THERAPY ; NANOPARTICLES ; DELIVERY ; PHOTOSENSITIZATION ; NANOMATERIALS ; BIOMATERIALS ; OSTEOGENESIS ; ANGIOGENESIS ; NANOCARRIERS ; COMBINATION |
| Language | 英语 |
| WOS Research Area | Materials Science |
| Publisher | ELSEVIER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sic.ac.cn/handle/331005/28000 |
| Collection | 中国科学院上海硅酸盐研究所 |
| Recommended Citation GB/T 7714 | Liu, YQ,Lin, RC,Ma, LL,et al. Mesoporous bioactive glass for synergistic therapy of tumor and regeneration of bone tissue[J]. APPLIED MATERIALS TODAY,2020. |
| APA | Liu, YQ.,Lin, RC.,Ma, LL.,Zhuang, H.,Feng, C.,...&Wu, CT.(2020).Mesoporous bioactive glass for synergistic therapy of tumor and regeneration of bone tissue.APPLIED MATERIALS TODAY. |
| MLA | Liu, YQ,et al."Mesoporous bioactive glass for synergistic therapy of tumor and regeneration of bone tissue".APPLIED MATERIALS TODAY (2020). |
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