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Tracking the interaction of drug molecules with individual mesoporous amorphous calcium phosphate/ATP nanocomposites - an X-ray spectromicroscopy study
Jiang, YY; Wang, ZQ; Chen, JT; Li, J; Zhu, YJ; Liu, LJ; Guo, XX; Hu, YF; He, SS; Wu, J; Chen, F; Sham, TK
2020-06-21
Source PublicationPHYSICAL CHEMISTRY CHEMICAL PHYSICS
ISSN1463-9076
Issue23Pages:13108
SubtypeArticle
AbstractAdenosine triphosphate (ATP) biomolecules play critial roles in the biomineralization process during the formation of amorphous calcium phosphate composites (ACPC), and ACPC is an important drug carrier due to its significant advantages of biocompatibility and biodegradability. Hence, studying the behavior of ACPC nanodrug carriers is crucial to investigate the structural regulation of biomimetic minerals and calcium phosphate (CaP)-based drug delivery systems. However, it is difficult to probe these interactions using traditional characterization methods. In this paper, XANES analysis together with STXM successfully provided a method to reveal the interaction of ATP and drug molecules with individual mesoporous ACPC. We found that the adenosine and phosphate groups of ATP biomolecules coordinated with Ca(2+)and played critical roles in the formation of ACPC; drug molecules with the -COOH groups were linked to Ca(2+)viacarboxylic acid groups primarily by electrostatic interactions, and the N-containing ring structures within the drug molecules also coordinated with Ca2+.
DOI10.1039/d0cp00797h
WOS KeywordK-EDGE XANES ; SILICA NANOPARTICLES ; PHOSPHORUS SOURCE ; DISODIUM SALT ; BONE ; HYDROXYAPATITE ; ABSORPTION ; MICROSPHERES ; NUCLEATION ; DELIVERY
Language英语
WOS Research AreaChemistry ; Physics
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27967
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Jiang, YY,Wang, ZQ,Chen, JT,et al. Tracking the interaction of drug molecules with individual mesoporous amorphous calcium phosphate/ATP nanocomposites - an X-ray spectromicroscopy study[J]. PHYSICAL CHEMISTRY CHEMICAL PHYSICS,2020(23):13108.
APA Jiang, YY.,Wang, ZQ.,Chen, JT.,Li, J.,Zhu, YJ.,...&Sham, TK.(2020).Tracking the interaction of drug molecules with individual mesoporous amorphous calcium phosphate/ATP nanocomposites - an X-ray spectromicroscopy study.PHYSICAL CHEMISTRY CHEMICAL PHYSICS(23),13108.
MLA Jiang, YY,et al."Tracking the interaction of drug molecules with individual mesoporous amorphous calcium phosphate/ATP nanocomposites - an X-ray spectromicroscopy study".PHYSICAL CHEMISTRY CHEMICAL PHYSICS .23(2020):13108.
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