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Cellular architecture response to aspect ratio tunable nanoarrays
Dai, J; Gong, JK; Kong, N; Yao, Y
2020-06-21
Source PublicationNANOSCALE
ISSN2040-3364
Issue23Pages:12395
SubtypeArticle
AbstractNanoarrays have been emerging as popular nanostructure platforms to investigate both cell behaviors and biological functions, due to the cell architecture respondence to the biointerface of nanostructures. Herein, we developed a series of aspect ratio tunable nanoarrays through a metal-assisted chemical etching method. Nanoarrays including nanoneedles, nanopillars, and nanoclusters were fabricated with a controllable aspect ratio. We found that nanostructures with a high aspect ratio (>10) induced significant alterations of cell physiological behaviors such as surface attachment, architecture deformation, viability, proliferation and motility. The cells on nanostructures with a high aspect ratio exhibited reorganized actin stress fibers and vimentin filaments, as well as reduced focal adhesion. This research enlarges the diversity of nanostructures on nano-bio interface investigation, provides a new insight for the surface-dependent architecture of cells, and offers unbiased understanding of factors influencing cell physiology.
DOI10.1039/d0nr01003k
WOS KeywordEPITHELIAL-MESENCHYMAL TRANSITION ; MEMBRANE CURVATURE ; SILICON NANOPILLARS ; ADHESION ; FABRICATION ; FORCE ; CELLS ; ARRAY ; MANIPULATION ; DIAMETER
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
PublisherROYAL SOC CHEMISTRY
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Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27966
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Dai, J,Gong, JK,Kong, N,et al. Cellular architecture response to aspect ratio tunable nanoarrays[J]. NANOSCALE,2020(23):12395.
APA Dai, J,Gong, JK,Kong, N,&Yao, Y.(2020).Cellular architecture response to aspect ratio tunable nanoarrays.NANOSCALE(23),12395.
MLA Dai, J,et al."Cellular architecture response to aspect ratio tunable nanoarrays".NANOSCALE .23(2020):12395.
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