SIC OpenIR
In situphase-changeable 2D MXene/zein bio-injection for shear wave elastography-guided tumor ablation in NIR-II bio-window
Zhou, BG; Pu, YY; Lin, H; Yue, WW; Yin, HH; Yin, YF; Ren, WW; Zhao, CK; Chen, Y; Xu, HX
2020-06-28
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
Issue24Pages:5257
SubtypeArticle
AbstractLocalized tumor photothermal cancer ablation is a minimally invasive therapeutic modality for combating cancer, but it often suffers from low therapeutic efficacy and poor precision due to the poor accumulation and non-uniform distribution of used photothermal-conversion agents in tumor tissueviathe typical intravenous administration. To address this, an injectable and phase-changeable composite bio-injection consisting of biocompatible two-dimensional (2D) niobium carbide (Nb2C) MXene and the plant-originating protein, zein, has been engineered for near infrared (NIR)-II-triggered tumor photothermal ablation. Zein can respond to aqueous microenvironments and also external photo-triggers from the NIR-II bio-window (1064 nm), and transforms into a solid bio-implant after solvent exchange between ethanol and water. Which, thus, traps Nb2C MXene and heat, improving ablation efficiency and enabling the precise and complete eradication of 4T1 breast tumor cells without additional safety concerns. More significantly, shear wave elastography (SWE) as a deep-penetration imaging mode that can reflect the ablated outcomesviamonitoring tissue density variation, has been employed to guide the photo-thermal ablation process to further improve the ablation precision. Thus, this compatible and phase-changeable bio-injection capable of improving photo-thermal ablation efficiency holds great potential in clinical applications.
DOI10.1039/d0tb00519c
WOS KeywordPERCUTANEOUS ETHANOL INJECTION ; PHOTOTHERMAL THERAPY ; HEPATOCELLULAR-CARCINOMA ; DRUG-DELIVERY ; ZEIN ; NANOSHEETS
Language英语
WOS Research AreaMaterials Science
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27952
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Zhou, BG,Pu, YY,Lin, H,et al. In situphase-changeable 2D MXene/zein bio-injection for shear wave elastography-guided tumor ablation in NIR-II bio-window[J]. JOURNAL OF MATERIALS CHEMISTRY B,2020(24):5257.
APA Zhou, BG.,Pu, YY.,Lin, H.,Yue, WW.,Yin, HH.,...&Xu, HX.(2020).In situphase-changeable 2D MXene/zein bio-injection for shear wave elastography-guided tumor ablation in NIR-II bio-window.JOURNAL OF MATERIALS CHEMISTRY B(24),5257.
MLA Zhou, BG,et al."In situphase-changeable 2D MXene/zein bio-injection for shear wave elastography-guided tumor ablation in NIR-II bio-window".JOURNAL OF MATERIALS CHEMISTRY B .24(2020):5257.
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