Energy Conversion-Based Nanotherapy for Rheumatoid Arthritis Treatment

doi:10.3389/fbioe.2020.00652

SIC OpenIR

	Energy Conversion-Based Nanotherapy for Rheumatoid Arthritis Treatment
	Wang, PP; Li, A; Yu, LD; Chen, Y; Xu, D
	2020-07-10
Source Publication	FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
ISSN	2296-4185
Subtype	Review
Abstract	Rheumatoid arthritis (RA) is characterized by synovial hyperplasia and cartilage/bone destruction, which results in a high disability rate on human health and a huge burden on social economy. At present, traditional therapies based on drug therapy still cannot cure RA, in accompany with the potential serious side effects. Based on the development of nanobiotechnology and nanomedicine, energy conversion-based nanotherapy has demonstrated distinctive potential and performance in RA treatment. This strategy employs specific nanoparticles with intrinsic physiochemical properties to target lesions with the following activation by diverse external stimuli, such as light, ultrasound, microwave, and radiation. These nanoagents subsequently produce therapeutic effects or release therapeutic factors to promote necrotic apoptosis of RA inflammatory cells, reduce the concentration of related inflammatory factors, relieve the symptoms of RA, which are expected to ultimately improve the life quality of RA patients. This review highlights and discusses the versatile biomedical applications of energy conversion-based nanotherapy in efficient RA treatment, in together with the deep clarification of the facing challenges and further prospects on the final clinical translations of these energy conversion-based nanotherapies against RA.
DOI	10.3389/fbioe.2020.00652
WOS Keyword	DRUG-DELIVERY SYSTEMS ; SONODYNAMIC THERAPY ; PHOTODYNAMIC TREATMENT ; PHOTOTHERMAL THERAPY ; HYALURONIC-ACID ; NANOPARTICLES ; METHOTREXATE ; PATHOGENESIS ; OXYGEN ; MECHANISM
Language	英语
WOS Research Area	Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
Publisher	FRONTIERS MEDIA SA
Citation statistics
Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/27910
Collection	中国科学院上海硅酸盐研究所
Recommended Citation GB/T 7714	Wang, PP,Li, A,Yu, LD,et al. Energy Conversion-Based Nanotherapy for Rheumatoid Arthritis Treatment[J]. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,2020.
APA	Wang, PP,Li, A,Yu, LD,Chen, Y,&Xu, D.(2020).Energy Conversion-Based Nanotherapy for Rheumatoid Arthritis Treatment.FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY.
MLA	Wang, PP,et al."Energy Conversion-Based Nanotherapy for Rheumatoid Arthritis Treatment".FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020).

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