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PDA/Cu Bioactive Hydrogel with "Hot Ions Effect" for Inhibition of Drug-Resistant Bacteria and Enhancement of Infectious Skin Wound Healing
Xu, Q; Chang, ML; Zhang, Y; Wang, ED; Xing, M; Gao, L; Huan, ZG; Guo, F; Chang, J
2020-07-15
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Issue28Pages:31255
SubtypeArticle
AbstractQuick and effective sterilization of drug-resistant bacteria inevitably became an ever-growing global challenge. In this study, a multifunctional composite (PDA/Cu-CS) hydrogel mainly composed of polydopamine (PDA) and copper-doped calcium silicate ceramic (Cu-CS) was prepared. It was confirmed that PDA/copper (PDA/Cu) complexing in the composite hydrogel played a key role in enhancing the photothermal performance and antibacterial activity. Through a unique "hot ions effect", created by the heating of Cu ions through the photothermal effect of the composite hydrogel, the hydrogel showed high-efficiency, quick, and long-term inhibition of methicillin-resistant Staphylococcus aureus and Escherichia coli. In addition, the hydrogel possessed remarkable bioactivity to stimulate angiogenesis. The in vivo results confirmed that the "hot ions effect" of the composite hydrogel removed existing infection in the wound area efficiently and significantly promoted angiogenesis and collagen deposition during infectious skin wound healing. Our results suggested that the design of multifunctional hydrogels with "hot ions effect" may be an effective therapeutic approach for the treatment of infectious wounds.
DOI10.1021/acsami.0c08890
WOS KeywordANTIBACTERIAL ACTIVITY ; STAPHYLOCOCCUS-AUREUS ; ESCHERICHIA-COLI ; COPPER ; NANOPARTICLES ; COMBINATION ; EVOLUTION ; EFFICACY ; CU ; ANGIOGENESIS
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27903
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Xu, Q,Chang, ML,Zhang, Y,et al. PDA/Cu Bioactive Hydrogel with "Hot Ions Effect" for Inhibition of Drug-Resistant Bacteria and Enhancement of Infectious Skin Wound Healing[J]. ACS APPLIED MATERIALS & INTERFACES,2020(28):31255.
APA Xu, Q.,Chang, ML.,Zhang, Y.,Wang, ED.,Xing, M.,...&Chang, J.(2020).PDA/Cu Bioactive Hydrogel with "Hot Ions Effect" for Inhibition of Drug-Resistant Bacteria and Enhancement of Infectious Skin Wound Healing.ACS APPLIED MATERIALS & INTERFACES(28),31255.
MLA Xu, Q,et al."PDA/Cu Bioactive Hydrogel with "Hot Ions Effect" for Inhibition of Drug-Resistant Bacteria and Enhancement of Infectious Skin Wound Healing".ACS APPLIED MATERIALS & INTERFACES .28(2020):31255.
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