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Bioinspired Copper Single-Atom Catalysts for Tumor Parallel Catalytic Therapy
Lu, XY; Gao, SS; Lin, H; Yu, LD; Han, YH; Zhu, PA; Bao, WC; Yao, HL; Chen, Y; Shi, JL
2020-09-01
Source PublicationADVANCED MATERIALS
ISSN0935-9648
Issue36
SubtypeArticle
AbstractThe oxidation of intracellular biomolecules by reactive oxygen species (ROS) forms the basis for ROS-based tumor therapy. However, the current therapeutic modalities cannot catalyze H(2)O(2)and O(2)concurrently for ROS generation, thereby leading to unsatisfactory therapeutic efficacy. Herein, it is reported a bioinspired hollow N-doped carbon sphere doped with a single-atom copper species (Cu-HNCS) that can directly catalyze the decomposition of both oxygen and hydrogen peroxide to ROS, namely superoxide ion (O-2 center dot(-)) and the hydroxyl radical (center dot OH), respectively, in an acidic tumor microenvironment for the oxidation of intracellular biomolecules without external energy input, thus resulting in an enhanced tumor growth inhibitory effect. Notably, the Fenton reaction turnover frequency of Cu species in Cu-HNCS is approximate to 5000 times higher than that of Fe in commercial Fe(3)O(4)nanoparticles. Experimental results and density functional theory calculations reveal that the high catalytic activity of Cu-HNCS originates from the single-atom copper, and the calculation predicts a next-generation Fenton catalyst. This work provides an effective paradigm of tumor parallel catalytic therapy for considerably enhanced therapeutic efficacy.
DOI10.1002/adma.202002246
WOS KeywordOXYGEN REDUCTION ; ACTIVE-SITES ; CANCER ; GENERATION
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27893
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Lu, XY,Gao, SS,Lin, H,et al. Bioinspired Copper Single-Atom Catalysts for Tumor Parallel Catalytic Therapy[J]. ADVANCED MATERIALS,2020(36).
APA Lu, XY.,Gao, SS.,Lin, H.,Yu, LD.,Han, YH.,...&Shi, JL.(2020).Bioinspired Copper Single-Atom Catalysts for Tumor Parallel Catalytic Therapy.ADVANCED MATERIALS(36).
MLA Lu, XY,et al."Bioinspired Copper Single-Atom Catalysts for Tumor Parallel Catalytic Therapy".ADVANCED MATERIALS .36(2020).
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