Multifunctional bioactive Nd-Ca-Si glasses for fluorescence thermometry, photothermal therapy, and burn tissue repair

doi:10.1126/sciadv.abb1311

SIC OpenIR

	Multifunctional bioactive Nd-Ca-Si glasses for fluorescence thermometry, photothermal therapy, and burn tissue repair
	Ma, LL; Zhou, YL; Zhang, ZWB; Liu, YQ; Zhai, D; Zhuang, H; Li, Q; Yuye, JD; Wu, CT; Chang, J
	2020-08-01
Source Publication	SCIENCE ADVANCES
ISSN	2375-2548
Issue	32
Subtype	Article
Abstract	Photothermal therapy (PTT), an emerging tumor treatment technology, has attracted tremendous interest, but excessive heat will cause damage to surrounding healthy tissues. Therefore, in situ temperature monitoring during PTT is of great importance to determine optimal treatment temperature and repair heat-damaged normal tissues. Here, we report the preparation of multifunctional Nd-Ca-Si silicate glasses and glass/alginate composite hydrogels that not only have photothermal property but also emit fluorescence under 808-nm laser irradiation, and its fluorescence intensity is linearly correlated with in situ temperature. With this feature, optimal PTT temperature for effective tumor treatment with minimal normal tissue damage can be obtained. In addition, because of the bioactive silicate components, the composite hydrogel has bioactivity to repair heat damage caused by PTT. This implantable multifunctional material with unique temperature monitoring, photothermal function, and wound healing bioactivity can be used for localized thermal therapy.
DOI	10.1126/sciadv.abb1311
WOS Keyword	NANOPARTICLES ; ANGIOGENESIS ; NANOPROBES ; PHOSPHORS
Language	英语
WOS Research Area	Science & Technology - Other Topics
Publisher	AMER ASSOC ADVANCEMENT SCIENCE
Citation statistics	Cited Times:2[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/27858
Collection	中国科学院上海硅酸盐研究所
Recommended Citation GB/T 7714	Ma, LL,Zhou, YL,Zhang, ZWB,et al. Multifunctional bioactive Nd-Ca-Si glasses for fluorescence thermometry, photothermal therapy, and burn tissue repair[J]. SCIENCE ADVANCES,2020(32).
APA	Ma, LL.,Zhou, YL.,Zhang, ZWB.,Liu, YQ.,Zhai, D.,...&Chang, J.(2020).Multifunctional bioactive Nd-Ca-Si glasses for fluorescence thermometry, photothermal therapy, and burn tissue repair.SCIENCE ADVANCES(32).
MLA	Ma, LL,et al."Multifunctional bioactive Nd-Ca-Si glasses for fluorescence thermometry, photothermal therapy, and burn tissue repair".SCIENCE ADVANCES .32(2020).

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