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Multifunctional bioactive Nd-Ca-Si glasses for fluorescence thermometry, photothermal therapy, and burn tissue repair
Ma, LL; Zhou, YL; Zhang, ZWB; Liu, YQ; Zhai, D; Zhuang, H; Li, Q; Yuye, JD; Wu, CT; Chang, J
2020-08-01
Source PublicationSCIENCE ADVANCES
ISSN2375-2548
Issue32
SubtypeArticle
AbstractPhotothermal therapy (PTT), an emerging tumor treatment technology, has attracted tremendous interest, but excessive heat will cause damage to surrounding healthy tissues. Therefore, in situ temperature monitoring during PTT is of great importance to determine optimal treatment temperature and repair heat-damaged normal tissues. Here, we report the preparation of multifunctional Nd-Ca-Si silicate glasses and glass/alginate composite hydrogels that not only have photothermal property but also emit fluorescence under 808-nm laser irradiation, and its fluorescence intensity is linearly correlated with in situ temperature. With this feature, optimal PTT temperature for effective tumor treatment with minimal normal tissue damage can be obtained. In addition, because of the bioactive silicate components, the composite hydrogel has bioactivity to repair heat damage caused by PTT. This implantable multifunctional material with unique temperature monitoring, photothermal function, and wound healing bioactivity can be used for localized thermal therapy.
DOI10.1126/sciadv.abb1311
WOS KeywordNANOPARTICLES ; ANGIOGENESIS ; NANOPROBES ; PHOSPHORS
Language英语
WOS Research AreaScience & Technology - Other Topics
PublisherAMER ASSOC ADVANCEMENT SCIENCE
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27858
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Ma, LL,Zhou, YL,Zhang, ZWB,et al. Multifunctional bioactive Nd-Ca-Si glasses for fluorescence thermometry, photothermal therapy, and burn tissue repair[J]. SCIENCE ADVANCES,2020(32).
APA Ma, LL.,Zhou, YL.,Zhang, ZWB.,Liu, YQ.,Zhai, D.,...&Chang, J.(2020).Multifunctional bioactive Nd-Ca-Si glasses for fluorescence thermometry, photothermal therapy, and burn tissue repair.SCIENCE ADVANCES(32).
MLA Ma, LL,et al."Multifunctional bioactive Nd-Ca-Si glasses for fluorescence thermometry, photothermal therapy, and burn tissue repair".SCIENCE ADVANCES .32(2020).
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