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3D printed titanium scaffolds with ordered TiO2 nanotubular surface and mesoporous bioactive glass for bone repair
Zhao, PY; Liu, YQ; Li, T; Zhou, YL; Leeflang, S; Chen, L; Wu, CT; Zhou, J; Huan, ZG
2020-08-04
Source PublicationPROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL
ISSN1002-0071
Issue4Pages:502
SubtypeArticle
AbstractTitanium alloy scaffolds have recently gained substantial interest for the treatment of critical-size bone defect, particularly along with the maturity of the 3D printing technology that is capable of turning scaffold design ideas into real implants. As titanium alloys lack surface osteogenic activity, for improved biological performance of such scaffolds, surface modification is necessary. Various coating materials and coating methods have been explored. In this study, we developed a unique surface modification method to provide the surface of 3D printed titanium scaffolds with nano-sized structure and bioactive agent. Uniform, ordered TiO2 nanotube arrays were formed by applying two-step anodization, and then mesoporous bioactive glass (MBG) was loaded into nanotubes. The results of in vitro immersion testing showed that bioactive ions, i.e., Si and Ca ions, could be steadily and continuously released from MBG into basal medium. The assessment of the responses of hBMSCs confirmed that the surface-modified scaffolds supported the adhesion and proliferation of hBMSCs, indicating good surface cytocompatibility. The developed method of combining surface nanostructure and bioactive agent could be used as a new strategy to improve the osteogenic activity of 3D printed titanium alloy scaffolds.
DOI10.1016/j.pnsc.2020.08.009
WOS KeywordIN-VITRO BIOACTIVITY ; MECHANICAL-PROPERTIES ; GENE-EXPRESSION ; VIVO EVALUATION ; IMPLANTS ; HYDROXYAPATITE ; COATINGS ; OSSEOINTEGRATION ; MICROSTRUCTURE ; OSTEOGENESIS
Language英语
WOS Research AreaMaterials Science ; Science & Technology - Other Topics
PublisherELSEVIER SCIENCE INC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27852
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Zhao, PY,Liu, YQ,Li, T,et al. 3D printed titanium scaffolds with ordered TiO2 nanotubular surface and mesoporous bioactive glass for bone repair[J]. PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL,2020(4):502.
APA Zhao, PY.,Liu, YQ.,Li, T.,Zhou, YL.,Leeflang, S.,...&Huan, ZG.(2020).3D printed titanium scaffolds with ordered TiO2 nanotubular surface and mesoporous bioactive glass for bone repair.PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL(4),502.
MLA Zhao, PY,et al."3D printed titanium scaffolds with ordered TiO2 nanotubular surface and mesoporous bioactive glass for bone repair".PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL .4(2020):502.
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