SIC OpenIR
Construction of microneedle-assisted co-delivery platform and its combining photodynamic/immunotherapy
Chen, SX; Ma, M; Xue, FF; Shen, SZ; Chen, Q; Kuang, YC; Liang, KC; Wang, XL; Chen, HR
2020-08-10
Source PublicationJOURNAL OF CONTROLLED RELEASE
ISSN0168-3659
Pages218
SubtypeArticle
AbstractDespite advances in photodynamic therapy (PDT) for treating superficial tumor, the prospect of this monotherapy remains challenges in the context of systemic phototoxicity and poor efficacy. In this work, a physiologically self-degradable microneedle (MN)-assisted platform is developed for combining PDT and immunotherapy via controlled co-delivery of photosensitizer (PS) and checkpoint inhibitor anti-CTLA4 antibody (aCTLA4), which generates synergistic reinforcement outcome while reducing side effects. MN is composed of biocompatible hyaluronic acid integrated with the pH-sensitive dextran nanoparticles, which is fabricated to simultaneously encapsulate hydrophobic (Zinc Phthalocyanine) and hydrophilic agents (aCTLA4) via a double emulsion method. This co-loading carrier can aggregate effectively around topical tumor by microneedle-assisted transdermal delivery. In vivo studies using 4T1 mouse models, PDT firstly exerts its effect to killing tumor and triggers the immune responses, subsequently, facilitating the immunotherapy with immune checkpoint inhibitor (aCTLA4). The possible mechanism and systemic effects of the combined therapy are investigated, which demonstrate that this co-administration platform can be a promising tool for focal cancer treatment.
DOI10.1016/j.jconrel.2020.05.006
WOS KeywordCANCER-IMMUNOTHERAPY ; PHOTODYNAMIC THERAPY ; CHECKPOINT BLOCKADE ; TUMOR ; CELLS ; DRUG
Language英语
WOS Research AreaChemistry ; Pharmacology & Pharmacy
PublisherELSEVIER
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27842
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Chen, SX,Ma, M,Xue, FF,et al. Construction of microneedle-assisted co-delivery platform and its combining photodynamic/immunotherapy[J]. JOURNAL OF CONTROLLED RELEASE,2020:218.
APA Chen, SX.,Ma, M.,Xue, FF.,Shen, SZ.,Chen, Q.,...&Chen, HR.(2020).Construction of microneedle-assisted co-delivery platform and its combining photodynamic/immunotherapy.JOURNAL OF CONTROLLED RELEASE,218.
MLA Chen, SX,et al."Construction of microneedle-assisted co-delivery platform and its combining photodynamic/immunotherapy".JOURNAL OF CONTROLLED RELEASE (2020):218.
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