KMS Shanghai Institute of Ceramics，Chinese Academy of Sciences
| The Coppery Age: Copper (Cu)-Involved Nanotheranostics | |
| Dong, CH; Feng, W; Xu, WW; Yu, LD; Xiang, H; Chen, Y; Zhou, JQ | |
| 2020-11-01 | |
| Source Publication | ADVANCED SCIENCE
 |
| Issue | 21 |
| Subtype | Review |
| Abstract | As an essential trace element in the human body, transitional metal copper (Cu) ions are the bioactive components within the body featuring dedicated biological effects such as promoting angiogenesis and influencing lipid/glucose metabolism. The recent substantial advances of nanotechnology and nanomedicine promote the emerging of distinctive Cu-involved biomaterial nanoplatforms with intriguing theranostic performances in biomedicine, which are originated from the biological effects of Cu species and the physiochemical attributes of Cu-composed nanoparticles. Based on the very-recent significant progresses of Cu-involved nanotheranostics, this work highlights and discusses the principles, progresses, and prospects on the elaborate design and rational construction of Cu-composed functional nanoplatforms for a diverse array of biomedical applications, including photonic nanomedicine, catalytic nanotherapeutics, antibacteria, accelerated tissue regeneration, and bioimaging. The engineering of Cu-based nanocomposites for synergistic nanotherapeutics is also exemplified, followed by revealing their intrinsic biological effects and biosafety for revolutionizing their clinical translation. Finally, the underlying critical concerns, unresolved hurdles, and future prospects on their clinical uses are analyzed and an outlook is provided. By entering the "Copper Age," these Cu-involved nanotherapeutic modalities are expected to find more broad biomedical applications in preclinical and clinical phases, despite the current research and developments still being in infancy. |
| DOI | 10.1002/advs.202001549 |
| WOS Keyword | GUIDED PHOTOTHERMAL THERAPY ; MESOPOROUS BIOACTIVE GLASS ; SURFACE-PLASMON RESONANCE ; IRON-OXIDE NANOPARTICLES ; DRUG-DELIVERY SYSTEM ; ANTIBACTERIAL ACTIVITY ; CUS NANOPARTICLES ; CANCER-THERAPY ; INORGANIC NANOPARTICLES ; PHOTODYNAMIC THERAPY |
| Language | 英语 |
| WOS Research Area | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| Publisher | WILEY |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sic.ac.cn/handle/331005/27825 |
| Collection | 中国科学院上海硅酸盐研究所 |
| Recommended Citation GB/T 7714 | Dong, CH,Feng, W,Xu, WW,et al. The Coppery Age: Copper (Cu)-Involved Nanotheranostics[J]. ADVANCED SCIENCE,2020(21). |
| APA | Dong, CH.,Feng, W.,Xu, WW.,Yu, LD.,Xiang, H.,...&Zhou, JQ.(2020).The Coppery Age: Copper (Cu)-Involved Nanotheranostics.ADVANCED SCIENCE(21). |
| MLA | Dong, CH,et al."The Coppery Age: Copper (Cu)-Involved Nanotheranostics".ADVANCED SCIENCE .21(2020). |
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