KMS Shanghai Institute of Ceramics，Chinese Academy of Sciences
| Lithium silicate-based bioceramics promoting chondrocyte maturation by immunomodulating M2 macrophage polarization | |
| Zhai, D; Chen, L; Chen, Y; Zhu, YF; Xiao, Y; Wu, CT | |
| 2020-08-21 | |
| Source Publication | BIOMATERIALS SCIENCE
 |
| ISSN | 2047-4830 |
| Issue | 16Pages:4521 |
| Subtype | Article |
| Abstract | Articular cartilage lesions occur frequently but unfortunately the damaged cartilage has a very limited intrinsic repair capacity. Since the cartilage damage can cause sterile inflammation, the effects of inflammation on cartilage repair should be well understood for precise treatment. Our previous study showed that bioceramics play an important role in cartilage regeneration. However, it is unclear how the immune microenvironment induced by bioactive ceramics influences cartilage regeneration. In this study, we applied the model bioactive ceramic lithium calcium silicate (Li2Ca4Si4O13, LCS) to prepare scaffolds and explore whether LCS scaffolds could promote cartilage maturation by regulating macrophage polarization. It was found that LCS induced the shifting of macrophages to anti-inflammatory M2 phenotype by downregulating the expressions of inflammatory genes TNF alpha, IL-6 and IL-1 beta and promoting the expression of IL-10 genes. The conditioned medium from LCS-treated macrophages promoted the proliferation, migration and maturation of chondrocytes. In a chondrocyte and macrophage co-culture system, LCS scaffolds induced chondrocyte maturation. These results demonstrated that LCS significantly promoted chondrocyte maturation by immunomodulating the M2 macrophage polarization. Hence, LCS scaffolds have great potential in cartilage repair, indicating that bioceramics may be used in cartilage regeneration due to their immunomodulatory effects on macrophages. |
| DOI | 10.1039/d0bm00450b |
| WOS Keyword | OSTEOARTHRITIS ; CARTILAGE ; EXPRESSION |
| Language | 英语 |
| WOS Research Area | Materials Science |
| Publisher | ROYAL SOC CHEMISTRY |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sic.ac.cn/handle/331005/27818 |
| Collection | 中国科学院上海硅酸盐研究所 |
| Recommended Citation GB/T 7714 | Zhai, D,Chen, L,Chen, Y,et al. Lithium silicate-based bioceramics promoting chondrocyte maturation by immunomodulating M2 macrophage polarization[J]. BIOMATERIALS SCIENCE,2020(16):4521. |
| APA | Zhai, D,Chen, L,Chen, Y,Zhu, YF,Xiao, Y,&Wu, CT.(2020).Lithium silicate-based bioceramics promoting chondrocyte maturation by immunomodulating M2 macrophage polarization.BIOMATERIALS SCIENCE(16),4521. |
| MLA | Zhai, D,et al."Lithium silicate-based bioceramics promoting chondrocyte maturation by immunomodulating M2 macrophage polarization".BIOMATERIALS SCIENCE .16(2020):4521. |
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