Engineering of SPECT/Photoacoustic Imaging/Antioxidative Stress Triple-Function Nanoprobe for Advanced Mesenchymal Stem Cell Therapy of Cerebral Ischemia

doi:10.1021/acsami.0c10500

SIC OpenIR

	Engineering of SPECT/Photoacoustic Imaging/Antioxidative Stress Triple-Function Nanoprobe for Advanced Mesenchymal Stem Cell Therapy of Cerebral Ischemia
	Yao, MH; Shi, XJ; Zuo, CJ; Ma, M; Zhang, L; Zhang, HB; Li, X; Yang, GY; Tang, YH; Wu, R
	2020-08-26
Source Publication	ACS APPLIED MATERIALS & INTERFACES
ISSN	1944-8244
Issue	34 Pages:37885
Subtype	Article
Abstract	The precise transplantation, long-term tracking, and maintenance of stem cells with maximizing therapeutic effect are significant challenges in stem cell-based therapy for stroke treatment. In this study, a unique core-shell labeling nanoagent was prepared by encapsulating a cobalt protoporphyrin IX (CoPP)-loaded mesoporous silica nanoparticle (CPMSN) into a I-125-conjugated/spermine-modified dextran polymer (I-125-SD) by microfluidics for mesenchymal stem cell (MSC) tracking and activity maintenance. The CPMSN core not only exhibits excellent photoacoustic (PA) imaging performance induced by the intermolecular aggregation of CoPP within the mesopores but also protects the MSCs against oxidative stress by sustained release of CoPP. Meanwhile, the addition of a I-125-SD shell can increase the uptake efficiency in MSCs without inducing cell variability and enable the single-photon-emission computed tomography (SPECT) nuclear imaging. In vivo results indicated that CPMSN@I-125-SD labeling could allow for an optimal combination of instant imaging of MSCs, with PA to guide intracerebral injection, followed by multiple time point SPECT imaging to consecutively track the cell homing. Importantly, the sustained release of CoPP from CPMSN@I-125-SD significantly increased the survival of MSCs after injection into an ischemic mouse brain and promoted neurobehavioral recovery in ischemic mice. Thus, CPMSN@I-125-SD represents a robust theranostic probe for both MSC tracking and maintaining their therapeutic effect in the treatment of brain ischemia.
DOI	10.1021/acsami.0c10500
WOS Keyword	OXIDATIVE STRESS ; IN-VITRO ; STROKE ; TRACKING ; DEXTRAN ; TRANSPLANTATION ; ULTRASOUND ; DELIVERY ; BRAIN ; MRI
Language	英语
WOS Research Area	Science & Technology - Other Topics ; Materials Science
Publisher	AMER CHEMICAL SOC
Citation statistics	Cited Times:1[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/27813
Collection	中国科学院上海硅酸盐研究所
Recommended Citation GB/T 7714	Yao, MH,Shi, XJ,Zuo, CJ,et al. Engineering of SPECT/Photoacoustic Imaging/Antioxidative Stress Triple-Function Nanoprobe for Advanced Mesenchymal Stem Cell Therapy of Cerebral Ischemia[J]. ACS APPLIED MATERIALS & INTERFACES,2020(34):37885.
APA	Yao, MH.,Shi, XJ.,Zuo, CJ.,Ma, M.,Zhang, L.,...&Wu, R.(2020).Engineering of SPECT/Photoacoustic Imaging/Antioxidative Stress Triple-Function Nanoprobe for Advanced Mesenchymal Stem Cell Therapy of Cerebral Ischemia.ACS APPLIED MATERIALS & INTERFACES(34),37885.
MLA	Yao, MH,et al."Engineering of SPECT/Photoacoustic Imaging/Antioxidative Stress Triple-Function Nanoprobe for Advanced Mesenchymal Stem Cell Therapy of Cerebral Ischemia".ACS APPLIED MATERIALS & INTERFACES .34(2020):37885.

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