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Osteoblastic and anti-osteoclastic activities of strontium-substituted silicocarnotite ceramics: In vitro and in vivo studies
Zeng, JK; Guo, JS; Sun, ZY; Deng, FY; Ning, CQ; Xie, YZ
2020-09-01
Source PublicationBIOACTIVE MATERIALS
Issue3Pages:435
SubtypeArticle
AbstractOsteoporosis bone defect is a refractory orthopaedic disease which characterized by impaired bone quality and bone regeneration capacity. Current therapies, including antiosteoporosis drugs and artificial bone grafts, are not always satisfactory. Herein, a strontium-substituted calcium phosphate silicate bioactive ceramic (Sr-CPS) was fabricated. In the present study, the extracts of Sr-CPS were prepared for in vitro study and Sr-CPS scaffolds were used for in vivo study. The cytocompatibility, osteogenic and osteoclastogenic properties of Sr-CPS extracts were characterized in comparison to CPS. Molecular mechanisms were also evaluated by Western blot. Sr-CPS extracts were found to promote osteogenesis by upregulating Wnt/beta-catenin signal pathways and inhibit osteoclastogenesis through downregulating NF-kappa B signal pathway. In vivo, micro-CT, histological and histomorphometric observation were conducted after 8 weeks of implantation to evaluate the bone formation using calvarial defects model in ovariectomized rats. Compared with CPS, Sr-CPS significantly promoted critical sized ovariectomy (OVX) calvarial defects healing. Among all the samples, Sr-10 showed the best performance due to a perfect match of bone formation and scaffold degradation rates. Overall, the present study demonstrated that Sr-CPS ceramic can dually modulate both bone formation and resorption, which might be a promising candidate for the reconstruction of osteoporotic bone defect.
DOI10.1016/j.bioactmat.2020.03.008
WOS KeywordBONE ; SILICATE ; DIFFERENTIATION ; OSTEOPOROSIS ; CHEMISTRY ; FRACTURE ; CATENIN
Language英语
WOS Research AreaEngineering ; Materials Science
PublisherKEAI PUBLISHING LTD
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27795
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Zeng, JK,Guo, JS,Sun, ZY,et al. Osteoblastic and anti-osteoclastic activities of strontium-substituted silicocarnotite ceramics: In vitro and in vivo studies[J]. BIOACTIVE MATERIALS,2020(3):435.
APA Zeng, JK,Guo, JS,Sun, ZY,Deng, FY,Ning, CQ,&Xie, YZ.(2020).Osteoblastic and anti-osteoclastic activities of strontium-substituted silicocarnotite ceramics: In vitro and in vivo studies.BIOACTIVE MATERIALS(3),435.
MLA Zeng, JK,et al."Osteoblastic and anti-osteoclastic activities of strontium-substituted silicocarnotite ceramics: In vitro and in vivo studies".BIOACTIVE MATERIALS .3(2020):435.
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