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Near-Infrared Light-Triggered Chlorine Radical (Cl-.) Stress for Cancer Therapy
Song, RX; Wang, H; Zhang, M; Liu, YY; Meng, XF; Zhai, SJ; Wang, CC; Gong, T; Wu, YL; Jiang, XW; Bu, WB
2020-11-16
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
Issue47Pages:21032
SubtypeArticle
AbstractFree radicals with reactive chemical properties can fight tumors without causing drug resistance. Reactive oxygen species (ROS) has been widely used for cancer treatment, but regrettably, the common O(2)and H(2)O(2)deficiency in tumors sets a severe barrier for sufficient ROS production, leading to unsatisfactory anticancer outcomes. Here, we construct a chlorine radical (Cl-.) nano-generator with SiO2-coated upconversion nanoparticles (UCNPs) on the inside and Ag-0/AgCl hetero-dots on the outside. Upon near-infrared (NIR) light irradiation, the short-wavelength emission UCNP catalyzes(.)Cl generation from Ag-0/AgCl with no dependence on O-2/H2O2.Cl-. with strong oxidizing capacity and nucleophilicity can attack biomolecules in cancer cells more effectively than ROS. This(.)Cl stress treatment will no doubt broaden the family of oxidative stress-induced antitumor strategies by using non-oxygen free radicals, which is significant in the development of new anticancer agents.
DOI10.1002/anie.202007434
WOS KeywordAG-AT-AGCL ; HIGHLY EFFICIENT ; PHOTOCATALYTIC ACTIVITY ; OXIDATIVE STRESS ; STRAND BREAKS ; DEGRADATION ; UV/CHLORINE ; UV ; TRANSFORMATION ; CHEMISTRY
Language英语
WOS Research AreaChemistry
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27766
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Song, RX,Wang, H,Zhang, M,et al. Near-Infrared Light-Triggered Chlorine Radical (Cl-.) Stress for Cancer Therapy[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020(47):21032.
APA Song, RX.,Wang, H.,Zhang, M.,Liu, YY.,Meng, XF.,...&Bu, WB.(2020).Near-Infrared Light-Triggered Chlorine Radical (Cl-.) Stress for Cancer Therapy.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION(47),21032.
MLA Song, RX,et al."Near-Infrared Light-Triggered Chlorine Radical (Cl-.) Stress for Cancer Therapy".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION .47(2020):21032.
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