Tumor Cell Dissociation Removes Malignant Bladder Tumors

doi:10.1016/j.chempr.2020.06.013

SIC OpenIR

	Tumor Cell Dissociation Removes Malignant Bladder Tumors
	Bao, QQ; Hu, P; Ren, WW; Guo, YD; Shi, JL
	2020-09-10
Source Publication	CHEM
ISSN	2451-9294
Issue	9 Pages:2283
Subtype	Article
Abstract	Surgery and subsequent chemotherapy are still the most adopted clinical modalities for bladder cancer treatments with the inevitable operation risks, chemotherapy toxicity, and high recurrence rate. Here, we report an unprecedented tumor cell dissociation strategy for malignant bladder tumor removal without the needs of conventional surgery and chemotherapy. A common metal ion chelator, ethylene diamine tetraacetic acid (EDTA), has been loaded into the interlayers of neurotensin (NT)-modified Zn-Al layered double hydroxide (LDH). Under the targeting by NT, such a nano-platform shows high affinity to bladder tumor cells, leading to the highly selective and efficient accumulation at the bladder tumor site. The released EDTA molecules deprive Ca2+ from the intercellular calcium-dependent connexin by EDTA-Ca2+ chelation, resulting in the tumor disaggregation that is then safely excreted out of body rather than killed using toxic chemodrugs, thus, ensuring excellent biosafety and extraordinarily high effectiveness.
DOI	10.1016/j.chempr.2020.06.013
WOS Keyword	LAYERED DOUBLE HYDROXIDES ; RADICAL CYSTECTOMY ; MASPIN EXPRESSION ; DRUG-DELIVERY ; CANCER ; METASTASIS ; MIGRATION ; SURVIVAL ; CADHERIN ; PROTEIN
Language	英语
WOS Research Area	Chemistry
Publisher	CELL PRESS
Citation statistics
Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/27762
Collection	中国科学院上海硅酸盐研究所
Recommended Citation GB/T 7714	Bao, QQ,Hu, P,Ren, WW,et al. Tumor Cell Dissociation Removes Malignant Bladder Tumors[J]. CHEM,2020(9):2283.
APA	Bao, QQ,Hu, P,Ren, WW,Guo, YD,&Shi, JL.(2020).Tumor Cell Dissociation Removes Malignant Bladder Tumors.CHEM(9),2283.
MLA	Bao, QQ,et al."Tumor Cell Dissociation Removes Malignant Bladder Tumors".CHEM .9(2020):2283.

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