KMS Shanghai Institute of Ceramics，Chinese Academy of Sciences
| A tailored positively-charged hydrophobic surface reduces the risk of implant associated infections | |
| Shen, J; Gao, P; Han, S; Kao, RYT; Wu, SL; Liu, XY; Qian, S; Chu, PK; Cheung, KMC; Yeung, KWK | |
| 2020-09-15 | |
| Source Publication | ACTA BIOMATERIALIA
 |
| ISSN | 1742-7061 |
| Pages | 421 |
| Subtype | Article |
| Abstract | Implant-associated infections is one of the most challenging post-operative complications in bone-related implantations. To tackle this clinical issue, we developed a low-cost and durable surface coating for medical grade titanium implants that uses positively charged silane molecules. The in vitro antimicrobial tests revealed that the titanium surface coated with (3-aminopropyl) triethoxysilane, which has the appropriate length of hydrophobic alkyl chain and positive charged amino group, suppressed more than 90% of the initial bacterial adhesion of S. aureus, P. aeruginosa, and E. coli after 30 min of incubation. In terms of growth inhibitory rate, the treated surface was able to reduce 75.7% +/- 11.9% of bacterial growth after a 24-hour culturing, thereby exhibiting superior anti-biofilm formation in the late stage. When implanted into the rat model infected by S. aureus, the treated surface eliminated the implant-associated infection through the mechanism of inhibition of bacterial adhesion on the implant surface. Additionally, the treated surface was highly compatible with mammalian cells. In general, our design demonstrated its potential for human clinical trials as a low-cost and effective antibacterial strategy to minimize postoperative implant-related bacterial infection. (C) 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.actbio.2020.07.040 |
| WOS Keyword | IN-VITRO ; BACTERIAL ADHESION ; SILANE COATINGS ; ANTIBACTERIAL ; TITANIUM ; NANOPARTICLES ; BIOMATERIALS ; CYTOTOXICITY ; POLYMER ; DESIGN |
| Language | 英语 |
| WOS Research Area | Engineering ; Materials Science |
| Publisher | ELSEVIER SCI LTD |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sic.ac.cn/handle/331005/27751 |
| Collection | 中国科学院上海硅酸盐研究所 |
| Recommended Citation GB/T 7714 | Shen, J,Gao, P,Han, S,et al. A tailored positively-charged hydrophobic surface reduces the risk of implant associated infections[J]. ACTA BIOMATERIALIA,2020:421. |
| APA | Shen, J.,Gao, P.,Han, S.,Kao, RYT.,Wu, SL.,...&Yeung, KWK.(2020).A tailored positively-charged hydrophobic surface reduces the risk of implant associated infections.ACTA BIOMATERIALIA,421. |
| MLA | Shen, J,et al."A tailored positively-charged hydrophobic surface reduces the risk of implant associated infections".ACTA BIOMATERIALIA (2020):421. |
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