SIC OpenIR
A tailored positively-charged hydrophobic surface reduces the risk of implant associated infections
Shen, J; Gao, P; Han, S; Kao, RYT; Wu, SL; Liu, XY; Qian, S; Chu, PK; Cheung, KMC; Yeung, KWK
2020-09-15
Source PublicationACTA BIOMATERIALIA
ISSN1742-7061
Pages421
SubtypeArticle
AbstractImplant-associated infections is one of the most challenging post-operative complications in bone-related implantations. To tackle this clinical issue, we developed a low-cost and durable surface coating for medical grade titanium implants that uses positively charged silane molecules. The in vitro antimicrobial tests revealed that the titanium surface coated with (3-aminopropyl) triethoxysilane, which has the appropriate length of hydrophobic alkyl chain and positive charged amino group, suppressed more than 90% of the initial bacterial adhesion of S. aureus, P. aeruginosa, and E. coli after 30 min of incubation. In terms of growth inhibitory rate, the treated surface was able to reduce 75.7% +/- 11.9% of bacterial growth after a 24-hour culturing, thereby exhibiting superior anti-biofilm formation in the late stage. When implanted into the rat model infected by S. aureus, the treated surface eliminated the implant-associated infection through the mechanism of inhibition of bacterial adhesion on the implant surface. Additionally, the treated surface was highly compatible with mammalian cells. In general, our design demonstrated its potential for human clinical trials as a low-cost and effective antibacterial strategy to minimize postoperative implant-related bacterial infection. (C) 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
DOI10.1016/j.actbio.2020.07.040
WOS KeywordIN-VITRO ; BACTERIAL ADHESION ; SILANE COATINGS ; ANTIBACTERIAL ; TITANIUM ; NANOPARTICLES ; BIOMATERIALS ; CYTOTOXICITY ; POLYMER ; DESIGN
Language英语
WOS Research AreaEngineering ; Materials Science
PublisherELSEVIER SCI LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27751
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Shen, J,Gao, P,Han, S,et al. A tailored positively-charged hydrophobic surface reduces the risk of implant associated infections[J]. ACTA BIOMATERIALIA,2020:421.
APA Shen, J.,Gao, P.,Han, S.,Kao, RYT.,Wu, SL.,...&Yeung, KWK.(2020).A tailored positively-charged hydrophobic surface reduces the risk of implant associated infections.ACTA BIOMATERIALIA,421.
MLA Shen, J,et al."A tailored positively-charged hydrophobic surface reduces the risk of implant associated infections".ACTA BIOMATERIALIA (2020):421.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Shen, J]'s Articles
[Gao, P]'s Articles
[Han, S]'s Articles
Baidu academic
Similar articles in Baidu academic
[Shen, J]'s Articles
[Gao, P]'s Articles
[Han, S]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Shen, J]'s Articles
[Gao, P]'s Articles
[Han, S]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.