SIC OpenIR
Developing New Cancer Nanomedicines by Repurposing Old Drugs
Yang, BW; Shi, JL
2020-12-01
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
Issue49Pages:21829
SubtypeReview
AbstractThe high morbidity and mortality of cancer requires innovative therapeutics. Very recently, several old drugs approved by the U.S. Food and Drug Administration (FDA) or currently undergoing clinical trials, such as 2-deoxy-d-glucose, disulfiram, artemisinin, chloroquine, metformin, and aspirin, which have been extensively applied clinically for the treatment of other diseases with reliable evidence of biosafety, have been engineered into nanosystems for enhancing cancer therapy. These old drugs can cooperate with other components of nanosystems or the ambient biological environment, to favor tumor-specific therapeutics by nontoxicity-to-toxicity transition. This Minireview provides a concentrated summary of the most recent progress made in this emerging field, highlighting the "old drugs, new uses" strategy for the construction of next-generation nanomedicines. It is expected that the clinical translation of nanomedicines can be accelerated by repurposing old drugs to elevate cancer therapeutic efficacy and specificity.
DOI10.1002/anie.202004317
WOS KeywordINTRACELLULAR FATE ; COLORECTAL-CANCER ; PROSTATE-CANCER ; METABOLISM ; 2-DEOXY-D-GLUCOSE ; INHIBITION ; METFORMIN ; TARGETS ; NANOPARTICLES ; CHLOROQUINE
Language英语
WOS Research AreaChemistry
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27745
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Yang, BW,Shi, JL. Developing New Cancer Nanomedicines by Repurposing Old Drugs[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020(49):21829.
APA Yang, BW,&Shi, JL.(2020).Developing New Cancer Nanomedicines by Repurposing Old Drugs.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION(49),21829.
MLA Yang, BW,et al."Developing New Cancer Nanomedicines by Repurposing Old Drugs".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION .49(2020):21829.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yang, BW]'s Articles
[Shi, JL]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yang, BW]'s Articles
[Shi, JL]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yang, BW]'s Articles
[Shi, JL]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.