Developing New Cancer Nanomedicines by Repurposing Old Drugs

doi:10.1002/anie.202004317

SIC OpenIR

	Developing New Cancer Nanomedicines by Repurposing Old Drugs
	Yang, BW; Shi, JL
	2020-12-01
Source Publication	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN	1433-7851
Issue	49 Pages:21829
Subtype	Review
Abstract	The high morbidity and mortality of cancer requires innovative therapeutics. Very recently, several old drugs approved by the U.S. Food and Drug Administration (FDA) or currently undergoing clinical trials, such as 2-deoxy-d-glucose, disulfiram, artemisinin, chloroquine, metformin, and aspirin, which have been extensively applied clinically for the treatment of other diseases with reliable evidence of biosafety, have been engineered into nanosystems for enhancing cancer therapy. These old drugs can cooperate with other components of nanosystems or the ambient biological environment, to favor tumor-specific therapeutics by nontoxicity-to-toxicity transition. This Minireview provides a concentrated summary of the most recent progress made in this emerging field, highlighting the "old drugs, new uses" strategy for the construction of next-generation nanomedicines. It is expected that the clinical translation of nanomedicines can be accelerated by repurposing old drugs to elevate cancer therapeutic efficacy and specificity.
DOI	10.1002/anie.202004317
WOS Keyword	INTRACELLULAR FATE ; COLORECTAL-CANCER ; PROSTATE-CANCER ; METABOLISM ; 2-DEOXY-D-GLUCOSE ; INHIBITION ; METFORMIN ; TARGETS ; NANOPARTICLES ; CHLOROQUINE
Language	英语
WOS Research Area	Chemistry
Publisher	WILEY-V C H VERLAG GMBH
Citation statistics
Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/27745
Collection	中国科学院上海硅酸盐研究所
Recommended Citation GB/T 7714	Yang, BW,Shi, JL. Developing New Cancer Nanomedicines by Repurposing Old Drugs[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020(49):21829.
APA	Yang, BW,&Shi, JL.(2020).Developing New Cancer Nanomedicines by Repurposing Old Drugs.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION(49),21829.
MLA	Yang, BW,et al."Developing New Cancer Nanomedicines by Repurposing Old Drugs".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION .49(2020):21829.

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