Biodegradable Inorganic Nanostructured Biomaterials for Drug Delivery

doi:10.1002/admi.202000819

SIC OpenIR

	Biodegradable Inorganic Nanostructured Biomaterials for Drug Delivery
	Cai, AY; Zhu, YJ; Qi, C
	2020-10-01
Source Publication	ADVANCED MATERIALS INTERFACES
ISSN	2196-7350
Issue	20
Subtype	Review
Abstract	Biodegradable inorganic drug nanocarriers are widely investigated for efficient drug delivery with enhanced bioavailability and reduced side effects. An ideal drug nanocarrier should have high biocompatibility and good biodegradability to ensure high biosafety for applications in vivo. Many inorganic drug carriers including silica, metals, metal oxides, carbon-based materials are difficult to degrade, which may cause toxicity and restrict their clinical applications. Fortunately, biomineral-based drug nanocarriers including calcium phosphate, calcium carbonate, calcium silicate, etc. exhibit high biocompatibility and good biodegradability because they are the main inorganic constituents of biological hard tissues, and they can participate in the normal metabolism of the living body by dissolving into nontoxic ions. Thus, biomineral-based nanostructured materials are ideal biodegradable nanocarriers with high biocompatibility for drug delivery, and they are promising for clinical applications. In this review article, the recent advances of synthetic biomineral-based drug nanocarriers are discussed, and their characteristics, preparation, drug loading, and drug release, as well as their drug-delivery applications are highlighted. Finally, an outlook for the main future research directions and potential clinical applications of the synthetic biomineral-based drug nanocarriers is given.
DOI	10.1002/admi.202000819
WOS Keyword	CALCIUM-PHOSPHATE NANOPARTICLES ; ORGANIC PHOSPHORUS SOURCE ; ASSISTED RAPID SYNTHESIS ; 5'-TRIPHOSPHATE DISODIUM SALT ; POROUS HOLLOW MICROSPHERES ; BOVINE SERUM-ALBUMIN ; FRUCTOSE-1,6-BISPHOSPHATE TRISODIUM SALT ; MICROWAVE HYDROTHERMAL TRANSFORMATION ; GENERATING MINERALIZED NANOPARTICLES ; FREE SONOCHEMICAL SYNTHESIS
Language	英语
WOS Research Area	Chemistry ; Materials Science
Publisher	WILEY
Citation statistics
Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/27734
Collection	中国科学院上海硅酸盐研究所
Recommended Citation GB/T 7714	Cai, AY,Zhu, YJ,Qi, C. Biodegradable Inorganic Nanostructured Biomaterials for Drug Delivery[J]. ADVANCED MATERIALS INTERFACES,2020(20).
APA	Cai, AY,Zhu, YJ,&Qi, C.(2020).Biodegradable Inorganic Nanostructured Biomaterials for Drug Delivery.ADVANCED MATERIALS INTERFACES(20).
MLA	Cai, AY,et al."Biodegradable Inorganic Nanostructured Biomaterials for Drug Delivery".ADVANCED MATERIALS INTERFACES .20(2020).

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