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Biodegradable Inorganic Nanostructured Biomaterials for Drug Delivery
Cai, AY; Zhu, YJ; Qi, C
2020-10-01
Source PublicationADVANCED MATERIALS INTERFACES
ISSN2196-7350
Issue20
SubtypeReview
AbstractBiodegradable inorganic drug nanocarriers are widely investigated for efficient drug delivery with enhanced bioavailability and reduced side effects. An ideal drug nanocarrier should have high biocompatibility and good biodegradability to ensure high biosafety for applications in vivo. Many inorganic drug carriers including silica, metals, metal oxides, carbon-based materials are difficult to degrade, which may cause toxicity and restrict their clinical applications. Fortunately, biomineral-based drug nanocarriers including calcium phosphate, calcium carbonate, calcium silicate, etc. exhibit high biocompatibility and good biodegradability because they are the main inorganic constituents of biological hard tissues, and they can participate in the normal metabolism of the living body by dissolving into nontoxic ions. Thus, biomineral-based nanostructured materials are ideal biodegradable nanocarriers with high biocompatibility for drug delivery, and they are promising for clinical applications. In this review article, the recent advances of synthetic biomineral-based drug nanocarriers are discussed, and their characteristics, preparation, drug loading, and drug release, as well as their drug-delivery applications are highlighted. Finally, an outlook for the main future research directions and potential clinical applications of the synthetic biomineral-based drug nanocarriers is given.
DOI10.1002/admi.202000819
WOS KeywordCALCIUM-PHOSPHATE NANOPARTICLES ; ORGANIC PHOSPHORUS SOURCE ; ASSISTED RAPID SYNTHESIS ; 5'-TRIPHOSPHATE DISODIUM SALT ; POROUS HOLLOW MICROSPHERES ; BOVINE SERUM-ALBUMIN ; FRUCTOSE-1,6-BISPHOSPHATE TRISODIUM SALT ; MICROWAVE HYDROTHERMAL TRANSFORMATION ; GENERATING MINERALIZED NANOPARTICLES ; FREE SONOCHEMICAL SYNTHESIS
Language英语
WOS Research AreaChemistry ; Materials Science
PublisherWILEY
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Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27734
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Cai, AY,Zhu, YJ,Qi, C. Biodegradable Inorganic Nanostructured Biomaterials for Drug Delivery[J]. ADVANCED MATERIALS INTERFACES,2020(20).
APA Cai, AY,Zhu, YJ,&Qi, C.(2020).Biodegradable Inorganic Nanostructured Biomaterials for Drug Delivery.ADVANCED MATERIALS INTERFACES(20).
MLA Cai, AY,et al."Biodegradable Inorganic Nanostructured Biomaterials for Drug Delivery".ADVANCED MATERIALS INTERFACES .20(2020).
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