SIC OpenIR
Lysine demethylase KDM3A regulates nanophotonic hyperthermia resistance generated by 2D silicene in breast cancer
He, C; Yu, LD; Ding, L; Yao, HL; Chen, Y; Hao, YQ
2020-10-01
Source PublicationBIOMATERIALS
ISSN0142-9612
SubtypeArticle
AbstractBreast cancer (BC) is the most common malignant disease affecting women's health worldwide. The benefits from conventional therapeutic modalities are severely limited. An increasing number of promising photothermal materials have been recently developed and introduced into the therapeutic regimens of BC, but the underlying biological mechanism remains unclear. Silicon-based materials have enjoyed many popularities in the biomedical field owing to their desirable biocompatibility, biodegradability and versatility. Herein, we introduced two dimensional (2D) silicene nanosheets (SNSs) into the BC treatment and achieved profound photothermal-ablation efficacy. Importantly, this work reveals the underlying biological mechanism and regulation factors of photonic hyperthermia in BC. The RNA sequencing and immunoblot demonstrated that photothermia enhanced apoptosis in BC by activating caspase 3 and caspase 7. Importantly, knockdown of lysine demethylase KDM3A sensitized BC to photothermia epigenetically. It has been revealed that KDM3A could erase p53K372me1 and suppress the anti-cancer functions of p53, leading to the downregulation of pro-apoptotic proteins-PUMA and NOXA verified by Co-IP and ChIP-qPCR assays. Therefore, our results not only import near infrared light (NIR) induced photothermal ablation generated by SNSs-BSA into the BC treatment, but also clarify the underlying mechanism and regulation factors for further photothermal performance optimization and clinical translation.
DOI10.1016/j.biomaterials.2020.120181
WOS KeywordGENE-EXPRESSION ; P53 ACTIVITY ; HISTONE ; CHEMOTHERAPY ; METHYLATION ; MECHANISMS ; IMPACT ; JHDM2A ; PUMA
Language英语
WOS Research AreaEngineering ; Materials Science
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27726
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
He, C,Yu, LD,Ding, L,et al. Lysine demethylase KDM3A regulates nanophotonic hyperthermia resistance generated by 2D silicene in breast cancer[J]. BIOMATERIALS,2020.
APA He, C,Yu, LD,Ding, L,Yao, HL,Chen, Y,&Hao, YQ.(2020).Lysine demethylase KDM3A regulates nanophotonic hyperthermia resistance generated by 2D silicene in breast cancer.BIOMATERIALS.
MLA He, C,et al."Lysine demethylase KDM3A regulates nanophotonic hyperthermia resistance generated by 2D silicene in breast cancer".BIOMATERIALS (2020).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[He, C]'s Articles
[Yu, LD]'s Articles
[Ding, L]'s Articles
Baidu academic
Similar articles in Baidu academic
[He, C]'s Articles
[Yu, LD]'s Articles
[Ding, L]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[He, C]'s Articles
[Yu, LD]'s Articles
[Ding, L]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.